MicroRNAs: Meta-controllers of gene expression in synaptic activity emerge as genetic and diagnostic markers of human disease.
MicroRNAs: Meta-controllers of gene expression in synaptic activity emerge as genetic and diagnostic markers of human disease.
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MicroRNA：突触活性中基因表达的元控制者出现，作为人类疾病的遗传和诊断标记。
DOI：
10.1016/j.pharmthera.2011.01.004
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发表时间：
2011-04
影响因子：
13.5
通讯作者：
Saugstad, Julie
中科院分区：
文献类型：
--
作者：
Ceman, Stephanie;Saugstad, Julie
关键词：
MicroRNA是RNA的非蛋白质编码家族的成员。它们通过调节信使RNA靶点的翻译和/或稳定性来充当基因表达的调节剂。microRNA的发现彻底改变了细胞生物学领域，并永久改变了基因和蛋白质表达之间线性关系的流行观点。基因调控的复杂性增加既令人兴奋又令人生畏，因为新出现的证据支持microRNA在几乎所有细胞过程中的普遍作用。本文简要介绍了microRNA加工和RNA诱导沉默复合物的形成，重点是RNA结合蛋白在这一过程中的作用。我们还讨论了microRNA介导的翻译调节机制，特别是在树突棘的形成和功能，以及microRNA在突触可塑性中的作用。然后，我们讨论的证据改变microRNA功能的认知脑障碍，和基因突变的影响，揭示了改变microRNA功能和人类疾病的单核苷酸多态性分析。此外，我们提出的证据表明，改变microRNA在循环液，如血浆/血清中的表达可以与相关，并作为人类疾病的新的诊断生物标志物。
MicroRNAs are members of the non-protein-coding family of RNAs. They serve as regulators of gene expression by modulating the translation and/or stability of messenger RNA targets. The discovery of microRNAs has revolutionized the field of cell biology, and has permanently altered the prevailing view of a linear relationship between gene and protein expression. The increased complexity of gene regulation is both exciting and daunting, as emerging evidence supports a pervasive role for microRNAs in virtually every cellular process. This review briefly describes microRNA processing and formation of RNA-induced silencing complexes, with a focus on the role of RNA binding proteins in this process. We also discuss mechanisms for microRNA-mediated regulation of translation, particularly in dendritic spine formation and function, and the role of microRNAs in synaptic plasticity. We then discuss the evidence for altered microRNA function in cognitive brain disorders, and the effect of gene mutations revealed by single nucleotide polymorphism analysis on altered microRNA function and human disease. Further, we present evidence that altered microRNA expression in circulating fluids such as plasma/serum can correlate with, and serve as, novel diagnostic biomarkers of human disease.
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影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
影响因子：
4.1
作者：
Cheever A;Ceman S
通讯作者：
Ceman S
影响因子：
5.3
作者：
Baillat, David;Shiekhattar, Ramin
通讯作者：
Shiekhattar, Ramin
影响因子：
10.5
作者：
Caudy, AA;Myers, M;Hammond, SM
通讯作者：
Hammond, SM
DOI：
10.1084/jem.20080285
发表时间：
2008-10-27
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bousquet M;Quelen C;Rosati R;Mansat-De Mas V;La Starza R;Bastard C;Lippert E;Talmant P;Lafage-Pochitaloff M;Leroux D;Gervais C;Viguié F;Lai JL;Terre C;Beverlo B;Sambani C;Hagemeijer A;Marynen P;Delsol G;Dastugue N;Mecucci C;Brousset P
通讯作者：
Brousset P