Genital HSV-2 infection induces short-term NK cell memory.
Genital HSV-2 infection induces short-term NK cell memory.
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DOI：
10.1371/journal.pone.0032821
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Ashkar AA
中科院分区：
文献类型：
--
作者：
Abdul-Careem MF;Lee AJ;Pek EA;Gill N;Gillgrass AE;Chew MV;Reid S;Ashkar AA
NK细胞被称为先天免疫细胞，缺乏免疫记忆。最近，已经表明NK细胞记得与诱导接触超敏反应和巨细胞病毒感染的化学半抗原的接触。在这里，我们表明存在的NK细胞记忆HSV-2感染后。与来自未处理小鼠的NK细胞相比，用HSV-2 Ag刺激导致在30天前暴露于HSV-2的NK细胞中产生更高的IFNγ。更重要的是，NK细胞中IFNγ的产生增加不依赖于B-和T-淋巴细胞，并且对HSV-2 Ag具有特异性。我们还表明，先前暴露的NK细胞在B-和T-淋巴细胞自由的环境中介导对HSV-2感染的保护，并且它们是保护小鼠免受HSV-2感染所必需的。总的来说，NK细胞不依赖于B-和T-淋巴细胞而记住先前的HSV-2遭遇，导致在再次暴露时针对HSV-2介导的发病率和死亡率的保护。
NK cells are known as innate immune cells that lack immunological memory. Recently, it has been shown that NK cells remember encounters with chemical haptens that induce contact hypersensitivity and cytomegalovirus infection. Here, we show the existence of NK cell memory following HSV-2 infection. Stimulation with HSV-2 Ags led to higher IFNγ production in NK cells that were exposed 30 days previously to HSV-2, compared to NK cells from naïve mice. More importantly, this increased production of IFNγ in NK cells was independent of B- and T- lymphocytes and specific for the HSV-2 Ags. We also showed that previously exposed NK cells in a B- and T-lymphocyte free environment mediate protection against HSV-2 infection and they are necessary for the protection of mice against HSV-2 infection. Collectively, NK cells remember prior HSV-2 encounters independent of B- and T- lymphocytes leading to protection against HSV-2 mediated morbidity and mortality upon re-exposure.
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