Serotonin transporter gene moderates the development of emotional problems among children following bullying victimization.
Serotonin transporter gene moderates the development of emotional problems among children following bullying victimization.
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DOI：
10.1016/j.jaac.2010.01.024
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发表时间：
2010-08
影响因子：
13.3
通讯作者：
Caspi A
中科院分区：
文献类型：
--
作者：
Sugden K;Arseneault L;Harrington H;Moffitt TE;Williams B;Caspi A
欺负是一种故意和反复对难以自卫的人造成伤害的行为，是一种比较普遍的学龄现象。成为欺凌的受害者与广泛的情感问题有关;然而，并不是所有被欺凌的孩子都会继续发展这些问题。我们测试了这一假设，欺负受害和情绪问题之间的关系是由5-羟色胺转运体（5-HTT）基因的变化在2,232名英国儿童组成的环境风险（E风险）研究队列中调节。我们的数据支持这一假设，即儿童的欺凌受害导致他们发展的情绪问题，而5-HTTLPR的遗传变异缓和这种关系。具体来说，经常被欺负的SS基因型儿童在12岁时比SL或LL基因型儿童更容易出现情绪问题。此外，我们表明，这种遗传调节持续（a）控制后，儿童的受害前的情绪问题，通过评估5至12岁之间的问题的个体内变化，和（B）控制后，在同一家庭中长大的儿童共享的其他风险因素，通过比较情绪问题的双胞胎不一致的欺凌受害。这些发现进一步证明了5-HTTLPR可以调节暴露于压力事件后的情绪障碍风险。
Bullying is the act of intentionally and repeatedly causing harm to someone who has difficulty defending him or herself, and is a relatively wide-spread school-age phenomenon. Being the victim of bullying is associated with a broad spectrum of emotional problems; however, not all children who are bullied go on to develop such problems. We tested the hypothesis that the relationship between bullying victimization and emotional problems was moderated by variation in the serotonin transporter (5-HTT) gene in 2,232 British children comprising the Environmental Risk (E-Risk) study cohort. Our data supported the hypothesis that children's bullying victimization leads to their developing emotional problems, and that genetic variation in the 5-HTTLPR moderates this relationship. Specifically, frequently bullied children with the SS genotype were at greater risk of developing emotional problems at age 12 than children with the SL or LL genotype. Furthermore, we demonstrated that this genetic moderation persisted (a) after controlling for children's pre-victimization emotional problems by assessing intra-individual change in problems between ages 5 and 12 years, and (b) after controlling for other risk factors shared by children growing up in the same family by comparing emotional problems in twins discordant for bullying victimization. These findings are further evidence that the 5-HTTLPR moderates the risk of emotional disturbance after exposure to stressful events.
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DOI：
10.1111/j.1469-7610.2009.02149.x
发表时间：
2010-02
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Benjet C;Thompson RJ;Gotlib IH
通讯作者：
Gotlib IH
影响因子：
10.6
作者：
Carola, Valeria;Frazzetto, Giovanni;Gross, Cornelius
通讯作者：
Gross, Cornelius
影响因子：
--
作者：
Bond, L;Carlin, JB;Patton, G
通讯作者：
Patton, G
影响因子：
8
作者：
Arseneault, L;Walsh, E;Moffitt, TE
通讯作者：
Moffitt, TE
影响因子：
2.6
作者：
Hoekstra, Rosa A.;Bartels, Meike;Boomsma, Dorret I.
通讯作者：
Boomsma, Dorret I.