5-HTTLPR moderates the effect of relational peer victimization on depressive symptoms in adolescent girls.
5-HTTLPR moderates the effect of relational peer victimization on depressive symptoms in adolescent girls.
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DOI：
10.1111/j.1469-7610.2009.02149.x
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Gotlib IH
中科院分区：
文献类型：
--
作者：
Benjet C;Thompson RJ;Gotlib IH
关系同伴受害与内化症状有关。与男孩相比，女孩更有可能受到同龄人的关系伤害，也更有可能因受害而感到痛苦。虽然之前的研究报告称，血清素转运蛋白基因（5-HTTLPR）启动子区域的功能多态性可以调节压力生活事件对抑郁症状的影响，但本研究首次评估了这种多态性与同伴受害之间的相互作用，以预测年轻女孩的抑郁症状水平。参与者是 78 名 10 至 14 岁的女孩，目前或过去没有轴 I 障碍。对女孩进行了 5-HTTLPR 基因分型；同伴受害情况通过社会经历问卷进行评估，抑郁症状通过儿童抑郁量表进行评估。 5-HTTLPR 多态性本身并不能预测抑郁症状的水平；然而，5-HTTLPR 和关系同伴受害的相互作用是抑郁症状的重要预测因素。后续分析表明，同伴受害仅能显着预测短等位基因纯合女孩的抑郁症状水平，而不能预测长等位基因纯合女孩或短等位基因和长等位基因杂合女孩的抑郁症状水平。研究结果支持抑郁症的素质-压力模型：拥有两个 5-HTTLPR 短等位基因会导致青春期女孩在经历同伴关系受害时容易出现抑郁症状。这些发现还表明，至少对于具有遗传脆弱性的女孩而言，同伴关系受害是压力的重要来源，在监测和预防欺凌行为时应认识到这一点。
Relational peer victimization is associated with internalizing symptoms. Compared to boys, girls are more likely to be both relationally victimized by peers and distressed by the victimization. While previous studies have reported that a functional polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) moderates the effect of stressful life events on depressive symptoms, the present study is the first to evaluate the interaction of this polymorphism with relational peer victimization to predict level of depressive symptoms in young girls. Participants were 78 girls ages 10 to 14 who had no current or past Axis I disorder. Girls were genotyped for 5-HTTLPR; peer victimization was assessed with the Social Experiences Questionnaire, and depressive symptoms with the Children's Depression Inventory. The 5-HTTLPR polymorphism alone did not predict level of depressive symptoms; the interaction of 5-HTTLPR and relational peer victimization, however, was a significant predictor of depressive symptoms. Follow-up analyses indicated that peer victimization significantly predicted level of depressive symptoms only for girls who were homozygous for the short allele, and not for girls homozygous for the long allele or who were heterozygous for the short and long alleles. The findings support the diathesis-stress model of depression: having two 5-HTTLPR short alleles confers vulnerability to depressive symptoms in adolescent girls when they experience relational peer victimization. These findings also suggest that relational peer victimization, at least for girls with genetic vulnerability, is a significant source of stress and should be recognized in the monitoring and prevention of bullying.
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影响因子：
10.6
作者：
Kaufman, J;Yang, BZ;Gelernter, J
通讯作者：
Gelernter, J
影响因子：
8
作者：
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DOI：
10.1098/rspb.2008.1788
发表时间：
2009-05-22
期刊：
Proceedings. Biological sciences
影响因子：
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作者：
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通讯作者：
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影响因子：
10.6
作者：
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通讯作者：
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影响因子：
3.3
作者：
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通讯作者：
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