Infant hair cortisol: associations with salivary cortisol and environmental context.
Infant hair cortisol: associations with salivary cortisol and environmental context.
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DOI：
10.1002/dev.21449
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发表时间：
2017-01
影响因子：
2.2
通讯作者：
Tarullo AR
中科院分区：
文献类型：
--
作者：
Flom M;St John AM;Meyer JS;Tarullo AR
早期慢性压力对身体和精神健康结果具有持久的影响。头发皮质醇浓度（HCC）已成为累积皮质醇暴露的标志，但HCC在婴儿中还没有得到很好的理解。我们研究了111名6个月和12个月大的婴儿HCC与广泛使用的基础唾液皮质醇测量、母体HCC和环境背景的关系。6个月和12个月的母亲HCC与12个月的婴儿HCC相关。12个月时，婴儿HCC与清醒唾液皮质醇浓度（SCC）、夜间SCC和曲线下面积（AUC）呈正相关，但与昼夜斜率无关。母乳喂养与较低的HCC相关，而睡眠中断增加与较平坦的斜坡相关。夜间睡眠时间的减少与更高的肝癌和更平坦的斜坡有关。以人为本的分析表明，高HCC和平坦的斜率相结合，与更多的环境风险，突出了HCC和昼夜皮质醇斜率之间的相互作用的重要性进行调查。结果支持HCC作为婴儿期累积皮质醇暴露的标志物的有效性，同时强调包括多个皮质醇测量评估下丘脑-肾上腺皮质-肾上腺（HPA）功能的不同方面的价值。
Early chronic stress has enduring implications for physical and mental health outcomes. Hair cortisol concentration (HCC) has emerged as a marker of cumulative cortisol exposure, yet HCC in infants is not well understood. We examined how infant HCC relates to widely used basal salivary cortisol measures, maternal HCC, and environmental context in 111 infants assessed at 6 and 12 months of age. Maternal HCC at 6 and 12 months was correlated with infant HCC at 12 months. At 12 months, infant HCC was positively associated with waking salivary cortisol concentration (SCC), evening SCC, and area under the curve (AUC), but was independent of diurnal slope. Breastfeeding was associated with lower HCC, whereas increased sleep disruption was related to flatter slope. Reduced nighttime sleep duration was related both to higher HCC and to flatter slope. A person-focused analysis indicated that the combination of high HCC and flattened slope was associated with more environmental risks, highlighting the importance of investigating the interplay between HCC and diurnal cortisol slope. Results support the validity of HCC as a marker of cumulative cortisol exposure in infancy, while emphasizing the value of including multiple cortisol measures assessing distinct aspects of Hypothalamic-Pituitary-Adrenal (HPA) function.
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影响因子：
4.6
作者：
Blair C;Granger DA;Willoughby M;Mills-Koonce R;Cox M;Greenberg MT;Kivlighan KT;Fortunato CK;FLP Investigators
通讯作者：
FLP Investigators
DOI：
10.1001/archpediatrics.2010.54
发表时间：
2010-05-01
影响因子：
--
作者：
Bernard, Kristin;Butzin-Dozier, Zachary;Dozier, Mary
通讯作者：
Dozier, Mary
影响因子：
2.2
作者：
Ben-Dat Fisher, Dahlia;Serbin, Lisa A.;Schwartzman, Alex E.
通讯作者：
Schwartzman, Alex E.
影响因子：
5.5
作者：
Anda, Robert F.;Butchart, Alexander;Brown, David W.
通讯作者：
Brown, David W.
影响因子：
2.6
作者：
Bartels, M;de Geus, EJC;Boomsma, DI
通讯作者：
Boomsma, DI