Mindfulness practice leads to increases in regional brain gray matter density.
Mindfulness practice leads to increases in regional brain gray matter density.
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DOI：
10.1016/j.pscychresns.2010.08.006
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发表时间：
2011-01-30
影响因子：
2.3
通讯作者：
Lazar, Sara W.
中科院分区：
文献类型：
--
作者：
Hoelzel, Britta K.;Carmody, James;Vangel, Mark;Congleton, Christina;Yerramsetti, Sita M.;Gard, Tim;Lazar, Sara W.
关键词：
结合正念冥想训练的治疗干预越来越受欢迎，但迄今为止，人们对与这些干预相关的神经机制知之甚少。正念减压（MBSR）是最广泛使用的正念训练计划之一，据报道，它对心理健康产生了积极影响，并改善了许多疾病的症状。在这里，我们报告了一项纵向对照研究，以调查在大脑灰质浓度的前后变化归因于参与MBSR计划。研究人员在16名健康的、未经冥想的参与者接受为期8周的项目之前和之后获得了他们的解剖MRI图像。灰质浓度的变化进行了调查，使用基于体素的形态测量，并比较了17个人的等待列表控制组。对先验感兴趣区域的分析证实了左侧海马内灰质浓度的增加。全脑分析发现，与对照组相比，正念减压疗法组的后扣带皮层、颞顶叶交界处和小脑都有所增加。结果表明，参与正念减压与参与学习和记忆过程、情绪调节、自我参照处理和观点采择的大脑区域的灰质浓度变化有关。
Therapeutic interventions that incorporate training in mindfulness meditation have become increasingly popular, but to date, little is known about neural mechanisms associated with these interventions. Mindfulness-Based Stress Reduction (MBSR), one of the most widely used mindfulness training programs, has been reported to produce positive effects on psychological well-being and to ameliorate symptoms of a number of disorders. Here, we report a controlled longitudinal study to investigate pre-post changes in brain gray matter concentration attributable to participation in an MBSR program. Anatomical MRI images from sixteen healthy, meditation-naïve participants were obtained before and after they underwent the eight-week program. Changes in gray matter concentration were investigated using voxel-based morphometry, and compared to a wait-list control group of 17 individuals. Analyses in a priori regions of interest confirmed increases in gray matter concentration within the left hippocampus. Whole brain analyses identified increases in the posterior cingulate cortex, the temporo-parietal junction, and the cerebellum in the MBSR group compared to the controls. The results suggest that participation in MBSR is associated with changes in gray matter concentration in brain regions involved in learning and memory processes, emotion regulation, self-referential processing, and perspective taking.
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