Tobacco Smoke and Endothelial Dysfunction: Role of Aldehydes?
Tobacco Smoke and Endothelial Dysfunction: Role of Aldehydes?
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DOI：
10.1007/s11906-020-01085-7
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发表时间：
2020-08-28
影响因子：
5.6
通讯作者：
Conklin DJ
中科院分区：
文献类型：
--
作者：
Lynch J;Jin L;Richardson A;Conklin DJ
吸烟是心血管疾病（CVD）发展中最重要的可改变风险因素。暴露于主流香烟烟雾（MCS）通过内皮功能障碍的发展与CVD相关，内皮功能障碍是一种以血管系统中血管活性因子失衡为特征的病症。这种功能障碍被认为是由MCS中高水平产生的醛类部分诱导的。电子烟（e-cigs）也可能导致CVD风险。虽然电子烟对健康的影响在很大程度上仍然是未知的，但电子烟气雾剂中存在醛类物质表明，电子烟可能会引起与MCS暴露相似的不良心血管后果。在此，我们回顾了传统和新兴烟草制品使用的研究，共同的有害和潜在有害成分，以及危害生物标志物（内皮功能障碍）的测量，以研究醛类在与香烟和电子烟使用相关的心血管危害中的潜在和独特作用。
Tobacco smoking is the most significant modifiable risk factor in the development of cardiovascular disease (CVD). Exposure to mainstream cigarette smoke (MCS) is associated with CVD through the development of endothelial dysfunction, a condition characterized by an imbalance of vasoactive factors in the vasculature. This dysfunction is thought to be induced in part by aldehydes generated at high levels in MCS. Electronic cigarettes (e-cigs) may also pose CVD risk. Although the health effects of e-cigs are still largely unknown, the presence of aldehydes in e-cig aerosol suggests that e-cigs may induce adverse cardiovascular outcomes similar to those seen with MCS exposure. Herein, we review studies of traditional and emerging tobacco product use, shared harmful and potentially harmful constituents, and measures of biomarkers of harm (endothelial dysfunction) to examine a potential and distinct role of aldehydes in cardiovascular harm associated with cigarette and e-cig use.
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影响因子：
37.8
作者：
Bhatnagar A;Whitsel LP;Ribisl KM;Bullen C;Chaloupka F;Piano MR;Robertson RM;McAuley T;Goff D;Benowitz N;American Heart Association Advocacy Coordinating Committee, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and Council on Quality of Care and Outcomes Research
通讯作者：
American Heart Association Advocacy Coordinating Committee, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and Council on Quality of Care and Outcomes Research
影响因子：
10.4
作者：
Alwis KU;deCastro BR;Morrow JC;Blount BC
通讯作者：
Blount BC
影响因子：
5.3
作者：
Antoniewicz, Lukasz;Bosson, Jenny A.;Lundback, Magnus
通讯作者：
Lundback, Magnus
影响因子：
19.7
作者：
Caporale, Alessandra;Langham, Michael C.;Wehrli, Felix W.
通讯作者：
Wehrli, Felix W.
影响因子：
9.8
作者：
Betteridge, DJ
通讯作者：
Betteridge, DJ