Canine model of ischemic stroke with permanent middle cerebral artery occlusion: clinical and histopathological findings.
Canine model of ischemic stroke with permanent middle cerebral artery occlusion: clinical and histopathological findings.
复制标题
伴有永久性大脑中动脉闭塞的缺血性中风的犬模型：临床和组织病理学结果。
DOI：
10.4142/jvs.2007.8.4.369
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发表时间：
2007-12
影响因子：
1.8
通讯作者：
Park, Hee-Myung
中科院分区：
文献类型：
--
作者：
Kang, Byeong-Teck;Lee, Jong-Hwan;Jung, Dong-In;Park, Chul;Gu, Su-Hyun;Jeon, Hyo-Won;Jang, Dong-Pyo;Lim, Chae-Young;Quan, Fu-Shi;Kim, Young-Bo;Cho, Zang-Hee;Woo, Eung-Je;Park, Hee-Myung
本研究的目的是评估犬缺血性脑卒中模型的临床和组织病理学结果。用硅胶塞封堵4只健康比格犬大脑中动脉诱导脑缺血。他们表现出前脑功能障碍的神经学症状，如反应性降低、头部转动、盘旋、姿势反应缺陷、知觉缺陷和偏盲。这些症状在未经治疗的4周内逐渐消退。mri表现为大脑皮层和基底节区T2高、T1低。病灶界限分明，与邻近脑实质明显分界，呈均匀状。脑脊液未见异常。尸检显示大脑皮层出现萎缩和坏死病变。大脑皮层、基底神经节和丘脑部分未被三苯基四氮唑氯染色。组织病理学上，在皮层和丘脑病变中发现了典型的梗死特征。这项研究表明，我们的狗模型与真正的中风患者的情况相似。
The aim of the present study was to assess the clinical and histopathological findings in a canine model of ischemic stroke. Cerebral ischemic stroke was induced by middle cerebral artery occlusion in four healthy beagle dogs using silicone plugs. They showed neurological signs of forebrain dysfunction such as reduced responsiveness, head turning, circling, postural reaction deficits, perceptual deficits, and hemianopsia. These signs gradually regressed within 4 weeks without therapy. On magnetic resonance imaging, T2 hyperintensity and T1 hypointensity were found in the cerebral cortex and basal ganglia. These lesions were well-defined and sharply demarcated from adjacent brain parenchyma with a homogenous appearance. No abnormalities of the cerebrospinal fluid were observed. At necropsy, atrophic and necrotic lesions were observed in the cerebral cortex. The cerebral cortex, basal ganglia, and thalamus were partially unstained with triphenyl-tetrazolium chloride. Histopathologically, typical features of infarction were identified in cortical and thalamic lesions. This study demonstrates that our canine model resembles the conditions of real stroke patients.
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影响因子：
2.6
作者：
Garosi, L;McConnell, JF;Schatzberg, SJ
通讯作者：
Schatzberg, SJ
影响因子：
2.6
作者：
Garosi, L;McConnell, JF;Schatzberg, SJ
通讯作者：
Schatzberg, SJ
DOI：
10.1016/s0195-5616(96)50112-9
发表时间：
1996-07-01
影响因子：
1.9
作者：
Thomas, WB
通讯作者：
Thomas, WB
影响因子：
8.3
作者：
Zausinger, S;Schöller, K;Schmid-Elsaesser, R
通讯作者：
Schmid-Elsaesser, R
影响因子：
4.8
作者：
GUO, J;LIAO, JJ;BATJER, HH
通讯作者：
BATJER, HH