The Relationship between Autism and Ehlers-Danlos Syndromes/Hypermobility Spectrum Disorders.
The Relationship between Autism and Ehlers-Danlos Syndromes/Hypermobility Spectrum Disorders.
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DOI：
10.3390/jpm10040260
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发表时间：
2020-12-01
影响因子：
--
通讯作者：
Casanova MF
中科院分区：
文献类型：
--
作者：
Casanova EL;Baeza-Velasco C;Buchanan CB;Casanova MF
关于遗传性结缔组织疾病如Ehlers-Danlos综合征（EDS）/高动性谱系障碍（HSD）和自闭症之间的关系，无论是在它们的共病还是在同一家族内的共病方面，都引起了相当大的兴趣。本文回顾了我们目前的知识状况，并强调了有关这一非凡患者群体的未回答的问题，我们希望这将在未来几年吸引更多的科学兴趣。特别是，患者本身要求对这一日益增长的兴趣领域进行更多的研究，尽管科学对这一呼吁的回应一直很慢。在这里，我们解决这两个频谱条件之间的重叠，包括神经行为，精神和神经共性，共享周围神经病变和神经病理，以及类似的自主神经和免疫失调。总之，这些数据突出了这两种情况的潜在相关性，并表明EDS/HSD可能代表自闭症的一种亚型。
Considerable interest has arisen concerning the relationship between hereditary connective tissue disorders such as the Ehlers-Danlos syndromes (EDS)/hypermobility spectrum disorders (HSD) and autism, both in terms of their comorbidity as well as co-occurrence within the same families. This paper reviews our current state of knowledge, as well as highlighting unanswered questions concerning this remarkable patient group, which we hope will attract further scientific interest in coming years. In particular, patients themselves are demanding more research into this growing area of interest, although science has been slow to answer that call. Here, we address the overlap between these two spectrum conditions, including neurobehavioral, psychiatric, and neurological commonalities, shared peripheral neuropathies and neuropathologies, and similar autonomic and immune dysregulation. Together, these data highlight the potential relatedness of these two conditions and suggest that EDS/HSD may represent a subtype of autism.
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