Effects of weekly low-frequency rTMS on autonomic measures in children with autism spectrum disorder.
Effects of weekly low-frequency rTMS on autonomic measures in children with autism spectrum disorder.
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DOI：
10.3389/fnhum.2014.00851
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发表时间：
2014
影响因子：
2.9
通讯作者：
Sears L
中科院分区：
文献类型：
--
作者：
Casanova MF;Hensley MK;Sokhadze EM;El-Baz AS;Wang Y;Li X;Sears L
自闭症谱系障碍（ASD）一词描述了一系列以社会交往、沟通障碍以及受限和重复行为为特征的疾病。自闭症谱系障碍也可能出现提示自主神经系统（ANS）功能障碍的症状。本研究的目的是通过记录每次低频重复经颅磁刺激（rTMS）前后和期间的心电图（ECG）和皮肤电活动（EDA），确定18次低频重复经颅磁刺激（rTMS）对ASD儿童自主神经功能的影响。本研究中感兴趣的自主测量是EKG中的R-R心动间期（R-R）、心率变异性（HRV）的时域和频域测量以及皮肤电导水平（SCL）。然后从记录的EKG导出心率变异性测量，例如R-R间期、心脏间期的标准差、pNN 50（与前一间期不同的心脏间期>50 ms的百分比）、HRV频谱的高频（HF）和LF分量的功率、LF/HF比。我们预期，应用于背外侧前额叶皮层（DLPFC）的18周抑制性LF rTMS过程将通过促进边缘系统活动的额叶抑制来增强自主神经平衡，从而导致总体心率（HR）降低、HRV增加（以HF功率增加的形式）、LF功率降低（导致LF/HF比率降低）和SCL降低。18 TMS后的行为评估显示，易怒，多动，刻板行为和强迫行为评级下降，而自主神经的措施表明，心脏间期变异性显着增加，紧张性SCL下降。结果表明，18个会议的LF rTMS在ASD的结果增加心脏迷走神经控制和减少交感神经唤醒。
The term autism spectrum disorder (ASD) describes a range of conditions characterized by impairments in social interactions, communication, and by restricted and repetitive behaviors. Autism spectrum disorder may also present with symptoms suggestive of autonomic nervous system (ANS) dysfunction. The objective of this study was to determine the effect of 18 sessions of low frequency (LF) repetitive transcranial magnetic stimulation (rTMS) on autonomic function in children with ASD by recording electrocardiogram (ECG) and electrodermal activity (EDA) pre- post- and during each rTMS session. The autonomic measures of interest in this study were R-R cardiointervals in EKG (R-R), time and frequency domain measures of heart rate variability (HRV) and skin conductance level (SCL). Heart rate variability measures such as R-R intervals, standard deviation of cardiac intervals, pNN50 (percentage of cardiointervals >50 ms different from preceding interval), power of high frequency (HF) and LF components of HRV spectrum, LF/HF ratio, were then derived from the recorded EKG. We expected that the course of 18 weekly inhibitory LF rTMS applied to the dorsolateral prefrontal cortex (DLPFC) would enhance autonomic balance by facilitating frontal inhibition of limbic activity thus resulting in decreased overall heart rate (HR), increased HRV (in a form of increased HF power), decreased LF power (resulting in decreased LF/HF ratio), and decreased SCL. Behavioral evaluations post-18 TMS showed decreased irritability, hyperactivity, stereotype behavior and compulsive behavior ratings while autonomic measures indicated a significant increase in cardiac interval variability and a decrease of tonic SCL. The results suggest that 18 sessions of LF rTMS in ASD results in increased cardiac vagal control and reduced sympathetic arousal.
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影响因子：
1.9
作者：
Casanova, MF;Buxhoeveden, DP;Brown, C
通讯作者：
Brown, C
影响因子：
4.6
作者：
Corona, R;Dissanayake, C;Sigman, M
通讯作者：
Sigman, M
影响因子：
10.6
作者：
Althaus, M;Mulder, LJM;Minderaa, RB
通讯作者：
Minderaa, RB
自闭症谱系障碍患者休息时自主神经和相关大脑活动异常
影响因子：
14.5
作者：
Eilam-Stock, Tehila;Xu, Pengfei;Fan, Jin
通讯作者：
Fan, Jin
影响因子：
3.7
作者：
Berntson, Gary G.;Norman, Greg J.;Cacioppo, John T.
通讯作者：
Cacioppo, John T.