Construction of multifunctional hydrogel based on the tannic acid-metal coating decorated MoS(2) dual nanozyme for bacteria-infected wound healing.
Construction of multifunctional hydrogel based on the tannic acid-metal coating decorated MoS(2) dual nanozyme for bacteria-infected wound healing.
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基于单宁酸-金属涂层修饰MoS2双纳米酶构建多功能水凝胶用于细菌感染伤口愈合
DOI：
10.1016/j.bioactmat.2021.07.023
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发表时间：
2022-03
影响因子：
18.9
通讯作者：
Fan D
中科院分区：
文献类型：
--
作者：
Li Y;Fu R;Duan Z;Zhu C;Fan D
细菌感染、组织缺氧和炎症反应可阻碍感染伤口的修复过程。为了缓解上述问题，开发了具有双酶活性的鞣酸螯合的Fe修饰的二硫化钼纳米片（MoS2@TA/Fe NS），并将其锚定到多功能水凝胶上。由于MoS2@TA/Fe NS的光热作用（PTT）、谷胱甘肽（GSH）的损失和过氧化物酶（POD）样活性（在酸性条件下催化H2O2转化为·OH）的综合作用，水凝胶表现出优异的抗菌能力。该水凝胶具有类过氧化氢酶（CAT）活性，能在中性条件下将H2O2分解为O2，缓解缺氧，提供充足的O2。POD样活性主要由MoS2 NS引起，CAT样活性主要由TA/Fe复合物引起。此外，MoS2@TA/Fe NS赋予水凝胶优异的抗氧化能力，在中性环境下清除多余的活性氧（ROS）和活性氮（RNS），维持抗氧化系统的平衡，预防炎症。此外，水凝胶可抑制炎症因子的释放，从而发挥TA的抗炎作用。TA保留了部分酚羟基，使纳米片与水凝胶的网络结构交联，促进了水凝胶的粘附。由于聚乙烯醇（PVA）、右旋糖酐（Dex）、MoS2@TA/Fe和Na2SO4之间的动态硼酯键，该水凝胶表现出快速的自愈合和快速的形状适应性。这种形状可适应的粘性水凝胶可以填充整个伤口，并与伤口紧密接触，确保其最大限度地发挥其功能。MoS2@TA/Fe纳米酶锚定的多功能水凝胶显示出细菌感染伤口愈合的高潜力。MoS2@TA/Fe NS呈现POD和CAT样活性。MoS2@TA/Fe纳米结构具有较好的抗氧化和抗炎作用。该水凝胶显示出快速的自愈合、可降解和快速的形状适应性。基于MoS2@TA/Fe NS的水凝胶在感染伤口愈合中表现出巨大的潜力。
Bacterial infection, tissue hypoxia and inflammatory response can hinder the infected wound repair process. To mitigate the above issues, tannic acid-chelated Fe-decorated molybdenum disulfide nanosheets (MoS2@TA/Fe NSs) with dual enzyme activities were developed and anchored to a multifunctional hydrogel. The hydrogel exhibited excellent antibacterial ability owing to the combined effects of photothermal therapy (PTT), glutathione (GSH) loss, and the peroxidase (POD)-like activity (catalyse H2O2 into ·OH under acid condition) of MoS2@TA/Fe NSs. Benefitting from the catalase (CAT)-like activity, the hydrogel could decompose H2O2 into O2 at neutral pH to relieve hypoxia and supply adequate O2. POD-like activity was mainly attributed to MoS2 NSs, while CAT-like activity was primarily due to TA/Fe complex. Moreover, MoS2@TA/Fe NSs endowed the hydrogel with outstanding anti-oxidant ability to scavenge redundant reactive oxygen species (ROS) and reactive nitrogen species (RNS) under neutral environment to maintain the balance of antioxidant systems and prevent inflammation. In addition, the hydrogel could inhibit the release of inflammatory factors for the anti-inflammatory property of TA. TA retained partial phenolic hydroxyl groups, which cross-linked the nanosheets to the network structure of the hydrogel and promoted the adhesion of hydrogels. Due to the dynamic boron ester bonds between polyvinyl alcohol (PVA), dextran (Dex), MoS2@TA/Fe, and borax, the hydrogel demonstrated fast self-healing and rapid shape adaptability. This shape-adaptable adhesive hydrogel could fill the whole wound and closely contact the wound, ensuring that it achieved its functions with maximum efficiency. The MoS2@TA/Fe nanozyme-anchored multifunctional hydrogel showed high potential for bacteria-infected wound healing. MoS2@TA/Fe NSs presents POD- and CAT-like activities. MoS2@TA/Fe NSs shows anti-oxidant and anti-inflammation abilities. The hydrogel shows fast self-healing, adhesiveness, and rapid shape-adaptivity. MoS2@TA/Fe NSs-based hydrogel exhibits large potential in infected wound healing.
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影响因子：
9.5
作者：
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通讯作者：
Liu, Jianfeng
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