Evaluating the Use of Silicone Wristbands To Measure Personal Exposure to Brominated Flame Retardants.
Evaluating the Use of Silicone Wristbands To Measure Personal Exposure to Brominated Flame Retardants.
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DOI：
10.1021/acs.est.8b03755
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发表时间：
2018-10-16
影响因子：
11.4
通讯作者：
Stapleton HM
中科院分区：
文献类型：
--
作者：
Hammel SC;Phillips AL;Hoffman K;Stapleton HM
生物标志物仍然是评估化学品暴露的黄金标准。然而，与单一生物标志物测量相比，硅胶腕带可以为表征个人暴露提供一些额外的好处，例如降低成本，非侵入性采样和增加分析的便利性。以前，我们验证了它们在表征有机磷酸盐阻燃剂（PFR）暴露方面的用途。然而，目前还不清楚这些结果是否会扩展到多溴联苯醚（PBDEs）等化学品，这些化学品具有生物放大作用，并且在体内的半衰期比全氟辛烷磺酸更长。这项研究试图确定腕带上多溴二苯醚的积累是否与血清生物标志物有关。成年参与者（n=30）提供血清样本，并佩戴腕带7天。测量腕带上的多溴二苯醚和6种新型溴化阻燃剂（BFR），并分析血清样本中的多溴二苯醚生物标志物。与大多数多溴二苯醚同源物一样，6种新型溴化阻燃剂中有5种经常在腕带上检测到（腕带的90%以上）。特别是，在本研究的所有腕带中均检测到十溴二苯乙烷（DBDPE），且与BDE-209存在显著相关性，表明其来源和接触途径相似。腕带中BDE-47、−99、−100和−153的浓度与相应的血清生物标志物显著正相关（rs=0.39-0.57，p<0.05）。这项研究表明，硅胶腕带可以准确地检测个人的多溴二苯醚暴露。
Biomarkers remain the gold standard for assessing chemical exposure. However, silicone wristbands may provide some added benefits for characterizing personal exposures compared to single biomarker measurements such as decreased costs, non-invasive sampling, and increased ease of analysis. Previously, we validated their use in characterizing exposure to organophosphate flame retardants (PFRs). However, it is unclear whether these results would extend to chemicals like polybrominated diphenyl ethers (PBDEs), which biomagnify and have longer half-lives than PFRs in the body. This study sought to determine if accumulation of PBDEs on wristbands was correlated to serum biomarkers. Adult participants (n=30) provided serum samples and wore wristbands for 7 days. PBDEs and 6 novel brominated flame retardants (BFRs) were measured on wristbands, and serum samples were analyzed for PBDE biomarkers. Like most PBDE congeners, 5 of 6 novel BFRs were detected on wristbands frequently (≥90% of bands). In particular, decabromodiphenyl ethane (DBDPE) was detected in all wristbands in this study and was significantly correlated with BDE-209, suggesting a similar source and exposure pathway. Wristband levels of BDE-47, −99, −100, and −153 were significantly and positively associated with respective serum biomarkers (rs=0.39–0.57, p<0.05). This study demonstrates that silicone wristbands can accurately detect personal PBDE exposures.
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影响因子：
11.4
作者：
Hammel SC;Hoffman K;Webster TF;Anderson KA;Stapleton HM
通讯作者：
Stapleton HM
影响因子：
9.8
作者：
Abbasi, Golnoush;Saini, Amandeep;Diamond, Miriam L.
通讯作者：
Diamond, Miriam L.
DOI：
10.1021/je010192t
发表时间：
2002-03-01
期刊：
JOURNAL OF CHEMICAL AND ENGINEERING DATA
影响因子：
--
作者：
Harner, T;Shoeib, M
通讯作者：
Shoeib, M
影响因子：
3.5
作者：
Belcher, Scott M.;Cookman, Clifford J.;Patisaul, Heather B.;Stapleton, Heather M.
通讯作者：
Stapleton, Heather M.
在家具泡沫，房屋灰尘水平和居民的血清水平中，火焰施用的阻燃应用之间的关联。
影响因子：
11.8
作者：
Hammel SC;Hoffman K;Lorenzo AM;Chen A;Phillips AL;Butt CM;Sosa JA;Webster TF;Stapleton HM
通讯作者：
Stapleton HM