The effects of combined perirhinal and postrhinal damage on complex discrimination tasks.
The effects of combined perirhinal and postrhinal damage on complex discrimination tasks.
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DOI：
10.1002/hipo.22063
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发表时间：
2012-10
期刊：
影响因子：
3.5
通讯作者：
Burwell, Rebecca D.
中科院分区：
文献类型：
--
作者：
Gastelum, Emily D.;Guilhardi, Paulo;Burwell, Rebecca D.
对合并损伤的大鼠进行复杂的识别任务，同时进行特征阳性和特征阴性识别任务的训练。在这项任务中，面板灯(L)与听觉刺激配对，决定音调(T)或白噪声(N)是奖励（+）还是不奖励（-）。因此，光特征决定了目标听觉刺激是否得到奖励。每次试验中，试验类型分别为LT+、T−、N+和LN−。我们假设对目标区域的损伤会影响这项任务的表现。受损大鼠的习得性发生了改变，但不是在预测的方向上。相反，受损大鼠表现出明显增强的识别习得。对间隔时间的操纵表明，主动干扰的减少并不能解释这种增强。在多线索间隔计时任务中，受损大鼠与对照组没有什么不同，这提供了证据，证明这种增强并不扩展到所有类型的辨别，也不是由于计时缺陷。其他研究表明，有嗅周损伤的大鼠在类似的任务中受损，因此这种增强可能是由于嗅后损伤的影响。通常在这项任务中，情境被认为对其他线索产生抑制控制。如果没有这种抑制控制，动物可能会更有效地学习任务。我们的结论是，在处理上下文信息的缺陷基础上，观察到在这个复杂的辨别任务中，大鼠的习得能力增强。
Rats with combined lesions of the perirhinal and postrhinal cortices were trained on a complex discrimination task, the simultaneous feature-positive and feature-negative discrimination task. In this task, a panel light (L) paired with an auditory stimulus determined whether a tone (T) or white noise (N) would be rewarded (+) or not rewarded (−). Thus, the light feature determined whether the target auditory stimuli were rewarded or not. In each session, trial types were LT+, T−, N+, and LN−. We had hypothesized that damage to the target regions would impair performance on this task. Acquisition was altered in the lesioned rats, but not in the predicted direction. Instead, lesioned rats exhibited significantly enhanced acquisition of the discrimination. Manipulation of intertrial intervals indicated that reduction of proactive interference did not explain the enhancement. Lesioned rats were not different from controls on a multiple cued-interval timing task, providing evidence that the enhancement does not extend to all types of discriminations and is not due to a deficit in timing. Other research shows that rats with perirhinal lesions are impaired on similar tasks, thus the enhancement is likely due to the effects of postrhinal damage. Normally in this task, context is thought to accrue inhibitory control over other cues. Without this inhibitory control, animals might be expected to learn the task more efficiently. Our conclusion is that deficits in processing contextual information underlie the enhanced acquisition observed in rats with combined perirhinal and postrhinal damage on this complex discrimination task.
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影响因子：
1.9
作者：
HOLLAND, PC;GALLAGHER, M
通讯作者：
GALLAGHER, M
DOI：
10.1037/0097-7403.17.3.231
发表时间：
1991-07-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES
影响因子：
--
作者：
HOLLAND, PC
通讯作者：
HOLLAND, PC
影响因子：
5.3
作者：
Bartko, Susan J.;Winters, Boyer D.;Bussey, Timothy J.
通讯作者：
Bussey, Timothy J.
影响因子：
1.9
作者：
Bucci, DJ;Saddoris, MP;Burwell, RD
通讯作者：
Burwell, RD
影响因子：
5.3
作者：
Burwell, RD;Bucci, DJ;Jutras, MJ
通讯作者：
Jutras, MJ