COVID-19 containment on a college campus via wastewater-based epidemiology, targeted clinical testing and an intervention.
COVID-19 containment on a college campus via wastewater-based epidemiology, targeted clinical testing and an intervention.
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DOI：
10.1016/j.scitotenv.2021.146408
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发表时间：
2021-07-20
期刊：
影响因子：
--
通讯作者：
Pepper IL
中科院分区：
文献类型：
--
作者：
Betancourt WQ;Schmitz BW;Innes GK;Prasek SM;Pogreba Brown KM;Stark ER;Foster AR;Sprissler RS;Harris DT;Sherchan SP;Gerba CP;Pepper IL
基于废水的流行病学有潜力成为确定社区中是否存在COVID-19的早期预警工具。亚利桑那大学（UArizona）利用WBE与临床测试相结合的监测工具，在秋季学生重返校园时，近乎实时地监测亚利桑那大学社区的SARS-CoV-2。废水中病毒RNA检测呈阳性导致选择临床试验，鉴定和隔离三名感染者（一名有症状者和两名无症状者），从而避免了潜在的疾病传播。本案例研究展示了WBE作为有效利用COVID-19预防和应对资源的工具的价值。因此，在秋季学期的课程中，我们进一步在13个宿舍进行了WBE结合针对性临床测试（表3）。总共有91份废水样本检测出SARS-CoV-2 RNA阳性，成功地为居住在宿舍的居民中至少一个新报告的感染病例（临床试验阳性）提供了预警。总体而言，WBE对新发病例的诊断准确率为82.0%，阴性预测值为88.9%。在与假日有关的活动之后，注意到阳性废水样本和临床试验的增加。然而，事实证明，就地收容政策在减少每日报告的阳性废水和临床试验数量方面是有效的。本案例研究为WBE与临床测试和公共卫生干预相结合，有效遏制特定社区中潜在的COVID-19爆发提供了证据。
Wastewater-based epidemiology has potential as an early-warning tool for determining the presence of COVID-19 in a community. The University of Arizona (UArizona) utilized WBE paired with clinical testing as a surveillance tool to monitor the UArizona community for SARS-CoV-2 in near real-time, as students re-entered campus in the fall. Positive detection of virus RNA in wastewater lead to selected clinical testing, identification, and isolation of three infected individuals (one symptomatic and two asymptomatic) that averted potential disease transmission. This case study demonstrated the value of WBE as a tool to efficiently utilize resources for COVID-19 prevention and response. Thus, WBE coupled with targeted clinical testing was further conducted on 13 dorms during the course of the Fall semester (Table 3). In total, 91 wastewater samples resulted in positive detection of SARS-CoV-2 RNA that successfully provided an early-warning for at least a single new reported case of infection (positive clinical test) among the residents living in the dorm. Overall, WBE proved to be an accurate diagnostic for new cases of COVID-19 with an 82.0% positive predictive value and an 88.9% negative predictive value. Increases in positive wastewater samples and clinical tests were noted following holiday-related activities. However, shelter-in-place policies proved to be effective in reducing the number of daily reported positive wastewater and clinical tests. This case study provides evidence for WBE paired with clinical testing and public health interventions to effectively contain potential outbreaks of COVID-19 in defined communities.
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DOI：
10.1016/j.cma.2020.113410
发表时间：
2020-12-01
影响因子：
7.2
作者：
Peirlinck M;Linka K;Sahli Costabal F;Bhattacharya J;Bendavid E;Ioannidis JPA;Kuhl E
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
12.6
作者：
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DOI：
10.1016/j.coesh.2020.09.006
发表时间：
2020-10
影响因子：
--
作者：
Medema G;Been F;Heijnen L;Petterson S
通讯作者：
Petterson S