Implementation of environmental surveillance for SARS-CoV-2 virus to support public health decisions: Opportunities and challenges.
Implementation of environmental surveillance for SARS-CoV-2 virus to support public health decisions: Opportunities and challenges.
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DOI：
10.1016/j.coesh.2020.09.006
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发表时间：
2020-10
影响因子：
--
通讯作者：
Petterson S
中科院分区：
文献类型：
--
作者：
Medema G;Been F;Heijnen L;Petterson S
分析废水可用于跟踪通过粪便和尿液传播的传染病病原体。有人建议将对SARS-CoV-2的污水监测作为一种工具，以确定COVID-19在城市中的程度，并作为社区中SARS-CoV-2循环（重新）出现的早期预警。本次审查的重点是证据的力量，机会和挑战的应用污水监测，为公共卫生决策提供信息。考虑进行采样程序进行审查，包括采样地点，战略，样本运输，储存和量化方法，连同方法和证据基础，从测量的废水浓度的感染率进行量化。对已发表的SARS-CoV-2污水监测研究（11项同行评审和10项预印本）进行了审查，以展示支持公共卫生决策的实施现状。尽管这一办法前景很好，但仍确定了一些需要进一步研究的领域，以进一步加强这一办法并充分利用其潜力。特别是，设计适当的采样策略，采样的空间和时间分辨率，样品储存，重复采样和分析，用于定量废水中SARS-CoV-2 RNA的分子方法的控制。使用适当的流行率数据和方法来关联，甚至翻译的SARS-CoV-2浓度在废水中的流行率的病毒散发者在人口中进行了讨论。使用24小时的复合样本，重复，控制和归一化提高SARS-CoV-2废水数据的适用性。病毒浓度可以用废水流量和人口或粪便标记标准化。废水SARS-CoV-2数据与社区流行率之间的相关性可以得到改善。趋势分析和预警为污水监测提供了最大的价值。从废水浓度推断流行率需要结合血清阳性率数据和流行病学模型。
Analysing wastewater can be used to track infectious disease agents that are shed via stool and urine. Sewage surveillance of SARS-CoV-2 has been suggested as a tool to determine the extent of COVID-19 in cities and serve as an early warning for (re-)emergence of SARS-CoV-2 circulation in communities. The focus of this review is on the strength of evidence, opportunities and challenges for the application of sewage surveillance to inform public health decision making. Considerations for undertaking sampling programs are reviewed including sampling sites, strategies, sample transport, storage and quantification methods; together with the approach and evidence base for quantifying prevalence of infection from measured wastewater concentration. Published SARS-CoV-2 sewage surveillance studies (11 peer reviewed and 10 preprints) were reviewed to demonstrate the current status of implementation to support public health decisions. Although being very promising, a number of areas were identified requiring additional research to further strengthen this approach and take full advantage of its potential. In particular, design of adequate sampling strategies, spatial and temporal resolution of sampling, sample storage, replicate sampling and analysis, controls for the molecular methods used for the quantification of SARS-CoV-2 RNA in wastewater. The use of appropriate prevalence data and methods to correlate or even translate SARS-CoV-2 concentrations in wastewater to prevalence of virus shedders in the population is discussed. Use of 24 h composite samples, replicates, controls and normalization improve applicability of SARS-CoV-2 wastewater data. Virus concentrations can be normalized with wastewater flows and population or faecal markers. Correlation between wastewater SARS-CoV-2 data and community prevalence can be improved. Trend analysis and early warning provide the most value for sewage surveillance. Inferring prevalence from wastewater concentration requires combination with seroprevalence data and epidemiological models.
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影响因子：
9.8
作者：
Coutu, Sylvain;Wyrsch, V.;Barry, D. A.
通讯作者：
Barry, D. A.
影响因子：
12.8
作者：
Crank, Katherine;Li, Xiang;Bibby, Kyle
通讯作者：
Bibby, Kyle
影响因子：
4.4
作者：
Been, Frederic;Schneider, Christian;Esseiva, Pierre
通讯作者：
Esseiva, Pierre
DOI：
10.3205/cto000071
发表时间：
2010
期刊：
GMS current topics in otorhinolaryngology, head and neck surgery
影响因子：
--
作者：
Beule AG
通讯作者：
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DOI：
10.1093/infdis/jiu384
发表时间：
2014-11-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
通讯作者：
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