Expression of MACC1 and c-Met in human gastric cancer and its clinical significance.
Expression of MACC1 and c-Met in human gastric cancer and its clinical significance.
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DOI：
10.1186/1475-2867-13-121
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发表时间：
2013-12-10
影响因子：
5.8
通讯作者：
Duan Y
中科院分区：
文献类型：
--
作者：
Guo T;Yang J;Yao J;Zhang Y;Da M;Duan Y
最近的研究表明转移相关结肠癌1（MACC 1）基因可通过上调c-Met表达促进肿瘤增殖、侵袭和转移。然而，它在胃癌中的作用是有争议的。我们的研究探讨了MACC 1和c-Met在胃癌中的表达，以及与临床病理参数的相关性。应用免疫组化方法检测98例胃癌及癌旁组织中MACC 1和c-Met蛋白的表达。分析它们之间的关系及与临床病理特征的相关性。MACC 1和c-Met蛋白在原发肿瘤中的阳性率分别为61.22%和59.18%。MACC 1与c-Met的表达呈显著相关（P<0.05）。MACC 1蛋白在胃癌组织中的表达与淋巴结转移有关（χ2 = 10.555，P = 0.001），腹膜转移（χ2 = 5.694，P = 0.017），肝转移与年龄、性别、肿瘤大小、部位、临床分期、远处转移无显著性差异（P>0.05）。MACC 1蛋白表达阳性率与c-Met蛋白表达阳性率相关。两者均与胃癌患者的腹膜转移、淋巴结转移和肝转移有关，所有这些都是胃癌患者预后不良的原因。
Recent studies have suggested that the metastasis-associated colon cancer1 (MACC1) gene can promote tumor proliferation, invasion and metastasis through an upregulation of c-Met expression. However, its role in gastric cancer is controversial. Our study investigated expression of MACC1 and c-Met in gastric cancer, as well as correlated this with clinicopathological parameters. Expressions of MACC1 and c-Met protein in a sample of 98 gastric carcinoma and adjacent nontumorous tissues were detected by immunohistochemistry. Their relationships and correlations with clinicopathological features were analyzed. The positive rates of MACC1 and c-Met protein in primary tumors were 61.22% and 59.18%, respectively. A significant correlation was found between expression of MACC1 and c-Met (P<0.05). Expression of the MACC1 protein in gastric cancer tissue was correlated with lymph node metastasis (χ2 = 10.555,P = 0.001), peritoneal metastasis (χ2 = 5.694, P = 0.017), and hepatic metastasis (χ2 = 4.540,P = 0.033), but not with age, gender, tumor size, location, clinical stage or the distant metastases (P>0.05). The positive rate of MACC1 protein expression was related to the protein expression of c-Met. Both had a correlation with the presence of peritoneal metastasis, lymph node metastasis and hepatic metastasis, all of which contribute to a poor prognosis for gastric cancer patients.
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影响因子：
4
作者：
Ogunwobi, Olorunseun O.;Liu, Chen
通讯作者：
Liu, Chen
影响因子：
2.5
作者：
Li, Yin;Chen, Chuang-Qi;Zan, Wen-Hua
通讯作者：
Zan, Wen-Hua
DOI：
10.1002/hed.21383
发表时间：
2010-12-01
影响因子：
2.9
作者：
Kim, Chul-Ho;Koh, Yoon Woo;Choi, Eun Chang
通讯作者：
Choi, Eun Chang
MACC1 鉴定为肝细胞癌的新型预后标志物
影响因子：
7.4
作者：
Qiu J;Huang P;Liu Q;Hong J;Li B;Lu C;Wang L;Wang J;Yuan Y
通讯作者：
Yuan Y
影响因子：
4.3
作者：
Lin, Yingsong;Ueda, Junko;Inoue, Manami
通讯作者：
Inoue, Manami