A sex-specific switch between visual and olfactory inputs underlies adaptive sex differences in behavior.
A sex-specific switch between visual and olfactory inputs underlies adaptive sex differences in behavior.
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DOI：
10.1016/j.cub.2020.12.047
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发表时间：
2021-03-22
期刊：
影响因子：
--
通讯作者：
Goodwin SF
中科院分区：
文献类型：
--
作者：
Nojima T;Rings A;Allen AM;Otto N;Verschut TA;Billeter JC;Neville MC;Goodwin SF
尽管雄性和雌性在很大程度上共享相同的基因组和神经系统，但它们在生殖投资方面存在巨大差异，需要不同的行为、形态和生理适应。神经系统在受到发育和生物物理约束的情况下，是如何在行为上产生这些性别差异的呢？在这里，我们发现了黑腹果蝇的一种新的二态性，这种二态性允许雄性和雌性在最小的电路结构变化下部署完全不同的行为。大脑中只有少数高级神经元的性别分化导致了与两性主要生殖需求相关的连通性的变化——雄性的求偶追求和雌性的共同产卵。这项研究解释了一个明显相似的大脑如何在两性中产生不同的行为，并提出了一个可能扩展到其他物种的神经回路组织的基本原则。双性表达的aDN神经元具有两性二态输入雄性aDN通过LC10视觉投射神经元接受视觉输入雌性aDN通过侧角接受嗅觉输入雄性aDN控制视觉求爱，雌性aDN控制公共产卵神经系统如何产生行为上的性别差异？Nojima等人报道了果蝇大脑中的一个两性二态神经元簇，它接收性别特异性的感觉信息：雄性求偶所需的视觉信号和雌性共同产卵所需的嗅觉信号。
Although males and females largely share the same genome and nervous system, they differ profoundly in reproductive investments and require distinct behavioral, morphological, and physiological adaptations. How can the nervous system, while bound by both developmental and biophysical constraints, produce these sex differences in behavior? Here, we uncover a novel dimorphism in Drosophila melanogaster that allows deployment of completely different behavioral repertoires in males and females with minimum changes to circuit architecture. Sexual differentiation of only a small number of higher order neurons in the brain leads to a change in connectivity related to the primary reproductive needs of both sexes—courtship pursuit in males and communal oviposition in females. This study explains how an apparently similar brain generates distinct behavioral repertoires in the two sexes and presents a fundamental principle of neural circuit organization that may be extended to other species. doublesex-expressing aDN neurons have sexually dimorphic inputs Male aDNs receive visual inputs via LC10 visual projection neurons Female aDNs receive olfactory inputs via the lateral horn aDNs control visual courtship pursuit in males and communal egg laying in females How does the nervous system produce sex differences in behavior? Nojima et al. report a sexually dimorphic neuronal cluster in the Drosophila brain that receives sex-specific sensory information: visual signals required for courtship pursuit in males and olfactory signals required for communal egg laying in females.
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影响因子：
64.5
作者：
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64.5
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通讯作者：
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影响因子：
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作者：
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