Development of hematopoietic stem and progenitor cells from human pluripotent stem cells.
Development of hematopoietic stem and progenitor cells from human pluripotent stem cells.
复制标题
从人类多能干细胞发育造血干细胞和祖细胞
DOI：
10.1002/jcb.25097
复制
发表时间：
2015-07
影响因子：
4
通讯作者：
Wang, Zack Z.
中科院分区：
文献类型：
--
作者：
Chen, Tong;Wang, Fen;Wu, Mengyao;Wang, Zack Z.
人多能干细胞（human pluripotent stem cells，hPSC）包括人胚胎干细胞（human embryonic stem cells，hESC）和人诱导多能干细胞（human induced pluripotent stem cells，hiPSCs），为再生医学、疾病建模、药物发现和临床前毒性筛选提供了新的细胞来源。了解hPSC分化后造血细胞的发生和序贯过程将有助于实现个体化医疗，并为研究人类造血发育和疾病提供体外平台。在胚胎发生过程中，生血内皮细胞是胚胎内皮细胞中的一个特定的内皮细胞亚群，是多能造血干细胞的主要来源。本文就造血干细胞经生血内皮细胞分化为多能造血干细胞和祖细胞的研究进展作一综述。我们还回顾了从非造血细胞到造血干细胞和祖细胞的直接重编程的成就。hPSC中造血分化的进一步表征将提高我们对血液发育的理解，并加快用于治疗目的的hPSC衍生血液制品的开发。J.细胞。116：1179-1189，2015.© 2015 Wiley Periodicals，Inc.
Human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), provide a new cell source for regenerative medicine, disease modeling, drug discovery, and preclinical toxicity screening. Understanding of the onset and the sequential process of hematopoietic cells from differentiated hPSCs will enable the achievement of personalized medicine and provide an in vitro platform for studying of human hematopoietic development and disease. During embryogenesis, hemogenic endothelial cells, a specified subset of endothelial cells in embryonic endothelium, are the primary source of multipotent hematopoietic stem cells. In this review, we discuss current status in the generation of multipotent hematopoietic stem and progenitor cells from hPSCs via hemogenic endothelial cells. We also review the achievements in direct reprogramming from non‐hematopoietic cells to hematopoietic stem and progenitor cells. Further characterization of hematopoietic differentiation in hPSCs will improve our understanding of blood development and expedite the development of hPSC‐derived blood products for therapeutic purpose. J. Cell. Biochem. 116: 1179–1189, 2015. © 2015 Wiley Periodicals, Inc.
登录
查看更多内容
影响因子：
64.8
作者：
Chen, Michael J.;Yokomizo, Tomomasa;Zeigler, Brandon M.;Dzierzak, Elaine;Speck, Nancy A.
通讯作者：
Speck, Nancy A.
影响因子：
2.6
作者：
Ferkowicz, MJ;Yoder, MC
通讯作者：
Yoder, MC
DOI：
10.1073/pnas.0604244103
发表时间：
2006-08-01
影响因子：
11.1
作者：
Galic, Zoran;Kitchen, Scott G.;Zack, Jerome A.
通讯作者：
Zack, Jerome A.
影响因子：
20.3
作者：
Amabile, Giovanni;Welner, Robert S.;Tenen, Daniel G.
通讯作者：
Tenen, Daniel G.
影响因子：
32.4
作者：
Cumano, A;Ferraz, JC;Godin, I
通讯作者：
Godin, I