Health-related quality of life in Chinese patients with mild and moderately active ulcerative colitis.
Health-related quality of life in Chinese patients with mild and moderately active ulcerative colitis.
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中国轻度和中度活动性溃疡性结肠炎患者的健康相关生活质量
DOI：
10.1371/journal.pone.0124211
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Shen H
中科院分区：
文献类型：
--
作者：
Zheng K;Zhang S;Wang C;Zhao W;Shen H
溃疡性结肠炎（UC）损害健康相关生活质量（HRQOL）。轻度和中度活动性UC患者之间的HRQOL差异尚未明确。很少有研究探讨影响中国患者HRQOL的因素。我们的研究目的是（1）比较轻度活动性UC患者与中度活动性UC患者的HRQOL;（2）探讨影响中国UC患者HRQOL的因素;（3）分析中国UC的人口统计学和疾病特征。方法选择110例轻度UC患者和114例中度UC患者作为研究对象。记录人口统计学和疾病特征。采用中文版炎症性肠病问卷（IBDQ）测定轻、中度患者、男性和女性患者以及不同疾病分布患者的HRQOL。逐步回归分析用于评估影响IBDQ评分的因素。结果中度UC患者IBDQ总分显著低于轻度UC患者（P=0.001）。IBDQ总分与马约评分呈负相关（r=-0.263，P<0.001）。逐步回归分析显示疾病活动指数和性别对IBDQ总分有影响（P<0.05）。女性患者在情感功能领域的得分低于男性患者（P<0.05），尤其是在情感功能领域（P=0.002）。不同疾病分布的IBDQ总分差异无统计学意义（P=0.183）。结论UC对HRQOL有负面影响。根据IBDQ测量，中度UC患者的HRQOL低于轻度UC患者的HRQOL。UC疾病活动度与HRQOL呈负相关。性别和疾病活动指数是影响中国UC患者HRQOL的重要因素。作为UC治疗的一部分，中国女性可能受益于增加的心理护理。
Background Ulcerative colitis (UC) impairs the health-related quality of life (HRQOL). The difference in HRQOL between patients with mild and moderately active UC is not well-defined. Few studies have been conducted to explore the factors that influence HRQOL in Chinese patients. Our study aims were to (1) compare HRQOL of mildly active UC patients with moderate patients; (2) explore the factors that influence HRQOL in Chinese patients with UC; and (3) analyze demographic and disease characteristics of UC in China. Methods A total of 110 mild and 114 moderate patients with UC were enrolled. The demographic and disease characteristics were recorded. HRQOL was measured by the Chinese version of the inflammatory bowel disease questionnaire (IBDQ) between mild and moderate patients, male and female patients, and different disease distributions. Stepwise regression analysis was used to assess factors influencing the IBDQ score. Results Patients with moderate UC had significantly lower IBDQ total scores compared to patients with mild UC (P=0.001). The IBDQ total score had a negative correlation with the Mayo score (r=–0.263, P<0.001). Stepwise regression analysis showed that the disease activity index and gender had an influence on the IBDQ total score (P<0.05). The female patients had a lower score than the male patients (P<0.05), especially in the emotional function domain (P=0.002). Different disease distributions were not statistically significant in the IBDQ total score (P=0.183). Conclusions UC has a negative influence on HRQOL. HRQOL in patients with moderate UC was lower than HRQOL in patients with mild UC, as measured by the IBDQ. UC disease activity has a negative correlation with HRQOL. Gender and the disease activity index are important factors involved in the impairment of HRQOL in Chinese patients with UC. Chinese females may benefit from increased psychological care as part of UC therapy.
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DOI：
10.1097/meg.0b013e3282f5e9c9
发表时间：
2008-07-01
影响因子：
2.1
作者：
Kuriyama, Motoaki;Katoa, Jun;Shiratori, Yasushi
通讯作者：
Shiratori, Yasushi
影响因子：
2.8
作者：
Kim, WH;Cho, YS;Lim, JG
通讯作者：
Lim, JG
影响因子：
3.5
作者：
Ouyang, Qin;Hu, Pin Jin;Hu, Ren Wei
通讯作者：
Hu, Ren Wei
影响因子：
7.2
作者：
Cheung, WY;Garratt, AM;Williams, JG
通讯作者：
Williams, JG
影响因子：
1.9
作者：
Bernklev, T;Jahnsen, J;Moum, B
通讯作者：
Moum, B