Parasympathetic and sympathetic nervous systems interactively predict change in cognitive functioning in midlife adults.
Parasympathetic and sympathetic nervous systems interactively predict change in cognitive functioning in midlife adults.
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DOI：
10.1111/psyp.13622
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发表时间：
2020-10
期刊：
影响因子：
3.7
通讯作者：
Almeida DM
中科院分区：
文献类型：
--
作者：
Knight EL;Giuliano RJ;Shank SW;Clarke MM;Almeida DM
自主神经系统（ANS）的两个分支分别与认知功能的变化有关：副交感神经系统（PNS）与健康的认知衰老有关，而过度的交感神经系统（SNS）活动与认知能力下降加剧有关。尽管有这些独立的发现，尽管ANS具有整体性，但很少有研究同时检查这两个分支，以更好地了解它们对中年成年人认知功能变化的相互作用。我们检查了美国中年（MIDUS）研究认知项目的两波认知变化，并分别从MIDUS生物标志物项目的心率变异性和肾上腺素水平索引了PNS和SNS活动（最小n = 843, 57.9%为女性，第一波平均年龄= 53.8岁）。我们的研究结果表明，面对认知挑战时，更大的PNS反应性（即更大的戒断和更大的恢复）与认知衰退的减轻有关，但仅在低SNS水平的个体中存在；当SNS水平较高时，PNS对认知能力下降的影响减弱。这些结果表明，未来针对ANS和认知衰老的研究应同时考虑ANS分支的作用。
The two branches of the autonomic nervous system (ANS) have been individually linked to changes in cognitive functioning: The parasympathetic nervous system (PNS) has been associated with healthy cognitive aging, whereas excessive sympathetic nervous system (SNS) activity has been linked to heightened cognitive decline. Despite these separate findings and despite the integrative nature of the ANS, little work has examined the two branches simultaneously to better understand their interactive effects on changes in cognitive functioning in midlife adults. We examined cognitive change in two waves of the Midlife in the United States (MIDUS) study cognitive project and indexed PNS and SNS activity from heart rate variability and epinephrine levels, respectively, from the MIDUS biomarker project (minimum n = 843, 57.9% female, mean age at first wave = 53.8 years). Our findings indicate that greater PNS responsivity (i.e., greater withdrawal and greater recovery) in response to cognitive challenge is associated with attenuated cognitive decline, but only among individuals with low SNS levels; at higher SNS levels, the effects of the PNS on cognitive decline are attenuated. These results suggest that future research targeting the ANS and cognitive aging should consider both ANS branch’s effects simultaneously.
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影响因子：
18.4
作者：
Erickson KI;Kramer AF
通讯作者：
Kramer AF
影响因子：
2.6
作者：
Crowley OV;Kimhy D;McKinley PS;Burg MM;Schwartz JE;Lachman ME;Tun PA;Ryff CD;Seeman TE;Sloan RP
通讯作者：
Sloan RP
DOI：
10.1016/j.biocel.2019.01.004
发表时间：
2019-03-01
影响因子：
4
作者：
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通讯作者：
Koch, Walter J.
影响因子：
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作者：
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通讯作者：
de Geus, EJC
影响因子：
3.7
作者：
Giuliano, Ryan J.;Karns, Christina M.;Pakulak, Eric
通讯作者：
Pakulak, Eric