The relationship between weight loss and health-related quality of life in persons treated for head and neck cancer.
The relationship between weight loss and health-related quality of life in persons treated for head and neck cancer.
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DOI：
10.1007/s00520-010-0975-x
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发表时间：
2011-10
影响因子：
3.1
通讯作者：
Pfeifer, Mark
中科院分区：
文献类型：
--
作者：
Head, Barbara A.;Heitz, Luke;Keeney, Cynthia;Myers, John;Appana, Savitri N.;Studts, Jamie L.;Bumpous, Jeffrey;Pfeifer, Mark
本研究探讨头颈癌患者体重减轻、健康相关生活质量（HRQOL）和症状负担之间的关系。参与者在治疗前、治疗中、治疗后完成肿瘤治疗-头颈部功能评估（FACT-H&N）和记忆症状评估量表（MSAS）。在治疗前和治疗后随访时记录体重，并将体重减轻的百分比制成表格。使用非参数Spearman rho评估体重减轻、HRQOL和症状负担之间的关系。建立了一个简单的线性回归模型，以预测的方式检查减肥对HRQOL的影响。每位患者的平均体重减轻12磅，模态值为19。研究发现，体重减轻与身体健康、功能健康、头颈部特定子量表和综合生活质量评分的下降显著相关。在体重减轻和症状负担之间没有发现显著的相关性。线性回归表明，基线体重下降10%导致FACT-H&N评分下降19%。体重减轻和HRQOL之间的密切联系支持了通过患者教育、积极监测和在治疗期间立即干预以停止或逆转体重减轻来预防体重减轻的重要性。应该开发和试验治疗患者体重减轻和消瘦的新方法。
This study explores the relationship between weight loss, health-related quality of life (HRQOL), and symptom burden in patients treated for head and neck cancers. Participants completed the Functional Assessment of Cancer Therapy—Head and Neck (FACT-H&N) and the Memorial Symptom Assessment Scale (MSAS) pre-treatment, mid-treatment, and post-treatment. Weights were recorded prior to treatment and at the post-treatment follow-up visit, and percentage weight loss was tabulated. Relationships between weight loss, HRQOL, and symptom burden were evaluated using the nonparametric Spearman rho. A simple linear regression model was developed to examine the influence weight loss has on HRQOL in a predictive manner. Average weight loss per patient was 12 lb with a modal value of 19. Weight loss was found to be significantly correlated with decreases in physical well-being, functional well-being, the Head and Neck specific subscale, and composite QOL scores. No significant correlations were found between weight loss and symptom burden as measured by the MSAS. Linear regression suggested that a 10% decrease in baseline weight resulted in a 19% decrease in the FACT-H&N score. The strong association between weight loss and HRQOL supports the importance of efforts to prevent weight loss via patient education, aggressive monitoring, and immediate intervention to stop or reverse weight loss during treatment. New approaches to the weight loss and wasting experienced by patients should be developed and tested.
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影响因子：
8.4
作者：
PORTENOY, RK;THALER, HT;SCHER, H
通讯作者：
SCHER, H
影响因子：
51.1
作者：
Quinten, Chantal;Coens, Corneel;Bottomley, Andrew
通讯作者：
Bottomley, Andrew
DOI：
10.1002/hed.20507
发表时间：
2007-03-01
影响因子：
2.9
作者：
Goldstein, David P.;Karnell, Lucy Hynds;Funk, Gerry F.
通讯作者：
Funk, Gerry F.
DOI：
10.1097/mco.0b013e3281e2c983
发表时间：
2007-07-01
影响因子：
3.1
作者：
Caro, Monica Maria Marin;Laviano, Alessandro;Pichard, Claude
通讯作者：
Pichard, Claude
影响因子：
8.8
作者：
Nelson, JE;Meier, DE;Morrison, RS
通讯作者：
Morrison, RS