The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study.
The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study.
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DOI：
10.1186/1471-2350-11-82
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发表时间：
2010-05-28
影响因子：
--
通讯作者：
Vogel U
中科院分区：
文献类型：
--
作者：
Andersen V;Ernst A;Christensen J;Østergaard M;Jacobsen BA;Tjønneland A;Krarup HB;Vogel U
克罗恩病（CD）和溃疡性结肠炎（UC）的特征是对遗传易感宿主肠道植物群正常成分的炎症反应失调。血红素氧合酶-1（HO-1/HMOX 1）是一种强有力的抗炎和抗氧化酶，而促炎白细胞介素1β（IL-1β/IL 1B）和抗炎白细胞介素10（IL-10/IL 10）是炎症发生和维持的关键调节因子。我们研究了IL-1β、IL-10和HO-1基因的单核苷酸多态性（SNP）以及吸烟是否与CD和UC的风险相关。IL-1β T-31 C等位基因频率（rs 1143627）和IL-10 rs3024505，G-1082 A（rs1800896），C-819 T（rs1800871），C-592A（rs 1800872）和HO-1 A-413 T（rs 2071746）使用病例对照设计在336名CD和498名UC患者以及779名健康对照的丹麦队列中评估SNP。采用Logistic回归模型估计OR值和95%CI。携带rs3024505（IL-10基因侧翼的标记多态性）的人患CD的风险增加（OR = 1.40，95%CI：1.06-1.85，P = 0.02）和UC（OR = 1.43，95%CI：1.12-1.82，P = 0.004），此外，在年轻时诊断CD和UC的风险（OR = 1.47，95%CI：1.10-1.96）和OR = 1.35，95%CI：1.04-1.76）。未发现IL-1β、IL-10 G-1082 A、C-819 T、C-592 A和HO-1基因多态性与CD或UC之间存在关联。吸烟状态和CD或UC基因型之间没有一致的相互作用。IL-10基因侧翼的rs3024505标记多态性与UC和CD的风险显著相关，而在这项丹麦研究中，IL-1β或HO-1基因多态性与CD和UC的风险之间没有发现相关性，表明IL-10而不是IL-1β或HO-1在该人群中的IBD病因中起作用。
Crohns disease (CD) and ulcerative colitis (UC) are characterized by a dysregulated inflammatory response to normal constituents of the intestinal flora in the genetically predisposed host. Heme oxygenase-1 (HO-1/HMOX1) is a powerful anti-inflammatory and anti-oxidant enzyme, whereas the pro-inflammatory interleukin 1β (IL-1β/IL1B) and anti-inflammatory interleukin 10 (IL-10/IL10) are key modulators for the initiation and maintenance of inflammation. We investigated whether single nucleotide polymorphisms (SNPs) in the IL-1β, IL-10, and HO-1 genes, together with smoking, were associated with risk of CD and UC. Allele frequencies of the IL-1β T-31C (rs1143627), and IL-10 rs3024505, G-1082A (rs1800896), C-819T (rs1800871), and C-592A (rs1800872) and HO-1 A-413T (rs2071746) SNPs were assessed using a case-control design in a Danish cohort of 336 CD and 498 UC patients and 779 healthy controls. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated by logistic regression models. Carriers of rs3024505, a marker polymorphism flanking the IL-10 gene, were at increased risk of CD (OR = 1.40, 95% CI: 1.06-1.85, P = 0.02) and UC (OR = 1.43, 95% CI: 1.12-1.82, P = 0.004) and, furthermore, with risk of a diagnosis of CD and UC at young age (OR = 1.47, 95% CI: 1.10-1.96) and OR = 1.35, 95% CI: 1.04-1.76), respectively). No association was found between the IL-1β, IL-10 G-1082A, C-819T, C-592A, and HO-1 gene polymorphisms and CD or UC. No consistent interactions between smoking status and CD or UC genotypes were demonstrated. The rs3024505 marker polymorphism flanking the IL-10 gene was significantly associated with risk of UC and CD, whereas no association was found between IL-1β or HO-1 gene polymorphisms and risk of CD and UC in this Danish study, suggesting that IL-10, but not IL-1β or HO-1, has a role in IBD etiology in this population.
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影响因子：
30.8
作者：
Fisher, Sheila A.;Tremelling, Mark;Anderson, Carl A.;Gwilliam, Rhian;Bumpstead, Suzannah;Prescott, Natalie J.;Nimmo, Elaine R.;Massey, Dunecan;Berzuini, Carlo;Johnson, Christopher;Barrett, Jeffrey C.;Cummings, Fraser R.;Drummond, Hazel;Lees, Charlie W.;Onnie, Clive M.;Hanson, Catherine E.;Blaszczyk, Katarzyna;Inouye, Mike;Ewels, Philip;Ravindrarajah, Radhi;Keniry, Andrew;Hunt, Sarah;Carter, Martyn;Watkins, Nick;Ouwehand, Willem;Lewis, Cathryn M.;Cardon, Lon;Lobo, Alan;Forbes, Alastair;Sanderson, Jeremy;Jewell, Derek P.;Mansfield, John C.;Deloukas, Panos;Mathew, Christopher G.;Parkes, Miles;Satsangi, Jack
通讯作者：
Satsangi, Jack
影响因子：
5.4
作者：
GREENLAND, S
通讯作者：
GREENLAND, S
影响因子：
4.5
作者：
Corleto, Vito D.;Pagnini, Cristiano;Delle Fave, Gianfranco
通讯作者：
Delle Fave, Gianfranco
DOI：
10.1084/jem.20051047
发表时间：
2005-12-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hegazi RA;Rao KN;Mayle A;Sepulveda AR;Otterbein LE;Plevy SE
通讯作者：
Plevy SE
影响因子：
30.8
作者：
Franke, Andre;Balschun, Tobias;Schreiber, Stefan
通讯作者：
Schreiber, Stefan