Parallel hippocampal-parietal circuits for self- and goal-oriented processing.
Parallel hippocampal-parietal circuits for self- and goal-oriented processing.
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DOI：
10.1073/pnas.2101743118
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发表时间：
2021-08-24
影响因子：
11.1
通讯作者：
Dosenbach NUF
中科院分区：
文献类型：
--
作者：
Zheng A;Montez DF;Marek S;Gilmore AW;Newbold DJ;Laumann TO;Kay BP;Seider NA;Van AN;Hampton JM;Alexopoulos D;Schlaggar BL;Sylvester CM;Greene DJ;Shimony JS;Nelson SM;Wig GS;Gratton C;McDermott KB;Raichle ME;Gordon EM;Dosenbach NUF
人类海马-皮质功能连接是非单一的，沿着前后轴的功能网络边界(默认模式网络[DMN]，自我导向；顶叶记忆网络[PMN]，目标导向)分离，这一发现提出了各种可能性，为什么这种组织可能是有益的，并可能为人类海马功能、记忆和自我的当前模型的更新提供信息。海马体对一系列不同的认知过程至关重要，如情景记忆、前瞻记忆、情感处理和空间导航。使用静息状态功能磁共振数据的个体特定的精确功能图，我们发现，正如预期的那样，前海马(头部和身体)优先功能连接到默认模式网络(DMN)。然而，海马尾部在功能上与顶叶记忆网络(PMN)有强烈的优先联系，PMN支持目标定向认知和刺激识别。这种静息状态功能连接的前后二分法与任务停用和海马体解剖分段的差异很好地匹配。任务失活局限于海马头和海马体(DMN)，相对较少激活尾部(PMN)。海马体分为前部DMN连接和后部PMN连接的神经节的功能二分法表明，在海马和顶叶内侧皮质之间存在平行但不同的回路，以进行自我与目标导向的加工。
The finding that human hippocampal-cortical functional connectivity is nonunitary, separated along functional network borders (default mode network [DMN], self-oriented; parietal memory network [PMN], goal-oriented) in the anterior–posterior axis, raises various possibilities as to why this organization might be beneficial and could inform updates to current models of human hippocampal function, memory, and the self. The hippocampus is critically important for a diverse range of cognitive processes, such as episodic memory, prospective memory, affective processing, and spatial navigation. Using individual-specific precision functional mapping of resting-state functional MRI data, we found the anterior hippocampus (head and body) to be preferentially functionally connected to the default mode network (DMN), as expected. The hippocampal tail, however, was strongly preferentially functionally connected to the parietal memory network (PMN), which supports goal-oriented cognition and stimulus recognition. This anterior–posterior dichotomy of resting-state functional connectivity was well-matched by differences in task deactivations and anatomical segmentations of the hippocampus. Task deactivations were localized to the hippocampal head and body (DMN), relatively sparing the tail (PMN). The functional dichotomization of the hippocampus into anterior DMN-connected and posterior PMN-connected parcels suggests parallel but distinct circuits between the hippocampus and medial parietal cortex for self- versus goal-oriented processing.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
16.2
作者：
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Dong, Hong-Wei
DOI：
10.1126/science.aan8869
发表时间：
2017-10-27
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
Buzsáki G;Llinás R
通讯作者：
Llinás R
DOI：
10.1073/pnas.1803667115
发表时间：
2018-10-02
影响因子：
11.1
作者：
Vos de Wael R;Larivière S;Caldairou B;Hong SJ;Margulies DS;Jefferies E;Bernasconi A;Smallwood J;Bernasconi N;Bernhardt BC
通讯作者：
Bernhardt BC
影响因子：
2.5
作者：
Braga, Rodrigo M.;Van Dijk, Koene R. A.;Buckner, Randy L.
通讯作者：
Buckner, Randy L.