Pre-natal exposures and breast tissue composition: findings from a British pre-birth cohort of young women and a systematic review.
Pre-natal exposures and breast tissue composition: findings from a British pre-birth cohort of young women and a systematic review.
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DOI：
10.1186/s13058-016-0751-z
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发表时间：
2016-10-12
期刊：
影响因子：
--
通讯作者：
Dos Santos Silva I
中科院分区：
文献类型：
--
作者：
Denholm R;De Stavola B;Hipwell JH;Doran SJ;Busana MC;Eng A;Jeffreys M;Leach MO;Hawkes D;Dos Santos Silva I
乳腺密度是女性年龄和体重指数下成人乳房中纤维腺组织的数量，是乳腺癌易感性的一个强有力的生物标志物，与乳腺癌风险本身一样，它可能会受到生命早期事件的影响。在本研究中，我们研究了产前暴露与乳腺组织成分之间的关联。来自英国产前队列的 500 名年轻未产妇（年龄约 21 岁）样本接受了乳房磁共振成像检查，以估计水分百分比，这是一种相当于乳房 X 光检查百分比密度的纤维腺组织相对量的测量方法。有关产前暴露的信息是在母亲怀孕期间和分娩后不久收集的。回归模型用于研究水百分比与产前暴露之间的关联。还进行了中介分析以及对已发表文献的系统回顾和荟萃分析。年轻女性调整后的水分百分比与母亲身高（线性趋势 p [p t] = 0.005）、中年母亲乳房 X 光密度（p t = 0.018）和参与者的出生尺寸（出生体重 p t < 0.001）呈正相关。出生时体重 (473 g)、身长 (2.3 cm)、头围 (1.2 cm) 和体重指数 (4.1 g/cm3) 的 1-SD 增量与 3 % (95 % CI 2–5 %)、2 % (95 % CI 0–3 %)、3 % (95 % CI 1–4 %) 和 1 % 相关(95% CI 0–3%) 分别增加平均调整值 水百分比。母亲身高对参与者水分百分比的影响部分是通过出生体重介导的，但几乎没有证据表明出生体重的影响主要是通过成年体型介导的。荟萃分析支持了研究结果，乳腺密度与出生尺寸呈正相关。这些发现提供了产前对乳腺组织成分影响的有力证据。出生体重与纤维腺组织相对数量之间的正相关表明，乳腺密度和乳腺癌风险可能具有共同的产前起源。本文的在线版本 (doi:10.1186/s13058-016-0751-z) 包含补充材料，可供授权用户使用。
Breast density, the amount of fibroglandular tissue in the adult breast for a women’s age and body mass index, is a strong biomarker of susceptibility to breast cancer, which may, like breast cancer risk itself, be influenced by events early in life. In the present study, we investigated the association between pre-natal exposures and breast tissue composition. A sample of 500 young, nulliparous women (aged approximately 21 years) from a U.K. pre-birth cohort underwent a magnetic resonance imaging examination of their breasts to estimate percent water, a measure of the relative amount of fibroglandular tissue equivalent to mammographic percent density. Information on pre-natal exposures was collected throughout the mothers’ pregnancy and shortly after delivery. Regression models were used to investigate associations between percent water and pre-natal exposures. Mediation analysis, and a systematic review and meta-analysis of the published literature, were also conducted. Adjusted percent water in young women was positively associated with maternal height (p for linear trend [p t] = 0.005), maternal mammographic density in middle age (p t = 0.018) and the participant’s birth size (p t < 0.001 for birthweight). A 1-SD increment in weight (473 g), length (2.3 cm), head circumference (1.2 cm) and Ponderal Index (4.1 g/cm3) at birth were associated with 3 % (95 % CI 2–5 %), 2 % (95 % CI 0–3 %), 3 % (95 % CI 1–4 %) and 1 % (95 % CI 0–3 %), respectively, increases in mean adjusted percent water. The effect of maternal height on the participants’ percent water was partly mediated through birth size, but there was little evidence that the effect of birthweight was primarily mediated via adult body size. The meta-analysis supported the study findings, with breast density being positively associated with birth size. These findings provide strong evidence of pre-natal influences on breast tissue composition. The positive association between birth size and relative amount of fibroglandular tissue indicates that breast density and breast cancer risk may share a common pre-natal origin. The online version of this article (doi:10.1186/s13058-016-0751-z) contains supplementary material, which is available to authorized users.
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DOI：
10.1158/1055-9965.epi-07-2547
发表时间：
2008-09
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Khazen M;Warren RM;Boggis CR;Bryant EC;Reed S;Warsi I;Pointon LJ;Kwan-Lim GE;Thompson D;Eeles R;Easton D;Evans DG;Leach MO;Collaborators in the United Kingdom Medical Research Council Magnetic Resonance Imaging in Breast Screening (MARIBS) Study
通讯作者：
Collaborators in the United Kingdom Medical Research Council Magnetic Resonance Imaging in Breast Screening (MARIBS) Study
影响因子：
2.3
作者：
Jeffreys, M;Warren, R;Smith, GD
通讯作者：
Smith, GD
影响因子：
3.8
作者：
Cerhan, JR;Sellers, TA;Vachon, CM
通讯作者：
Vachon, CM
DOI：
10.1093/jnci/87.9.670
发表时间：
1995-05-03
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
BOYD, NF;BYNG, JW;YAFFE, MJ
通讯作者：
YAFFE, MJ
影响因子：
7.4
作者：
Dorgan, Joanne F.;Klifa, Catherine;Hylton, Nola M.
通讯作者：
Hylton, Nola M.