Atypical protein phosphatases: emerging players in cellular signaling.
Atypical protein phosphatases: emerging players in cellular signaling.
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DOI：
10.3390/ijms14034596
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发表时间：
2013-02-26
影响因子：
5.6
通讯作者：
Takeda K
中科院分区：
文献类型：
--
作者：
Sadatomi D;Tanimura S;Ozaki K;Takeda K
一般认为，蛋白磷酸酶比蛋白激酶具有更多样化的催化结构域结构和机制；然而，人类基因组计划之后的基因注释工作似乎已经完成了整个蛋白磷酸酶序列。Ser/Thr磷酸酶分为三个结构不同的亚家族，而Tyr磷酸酶和针对Tyr、Ser和Thr的双特异性磷酸酶基于其共同的结构特征属于一个大家族。然而，几年来的研究揭示了一些意想不到的蛋白质的存在，这些蛋白质在这里被称为“非典型蛋白磷酸酶”，它们具有与已知蛋白磷酸酶不同的结构和酶特征，并参与重要的生物过程。本文综述了以眼缺失（eye absent， EYA）、t细胞受体信号抑制因子（Sts）和磷酸甘油酸突变酶家族成员5 （PGAM5）为代表的非典型蛋白磷酸酶的鉴定和功能特征，并讨论了它们在细胞信号传导中的生物学意义。
It has generally been considered that protein phosphatases have more diverse catalytic domain structures and mechanisms than protein kinases; however, gene annotation efforts following the human genome project appeared to have completed the whole array of protein phosphatases. Ser/Thr phosphatases are divided into three subfamilies that have different structures from each other, whereas Tyr phosphatases and dual-specificity phosphatases targeting Tyr, Ser and Thr belong to a single large family based on their common structural features. Several years of research have revealed, however, the existence of unexpected proteins, designated here as “atypical protein phosphatases”, that have structural and enzymatic features different from those of the known protein phosphatases and are involved in important biological processes. In this review, we focus on the identification and functional characterization of atypical protein phosphatases, represented by eyes absent (EYA), suppressor of T-cell receptor signaling (Sts) and phosphoglycerate mutase family member 5 (PGAM5) and discuss their biological significance in cellular signaling.
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影响因子：
3.7
作者：
Ishida Y;Sekine Y;Oguchi H;Chihara T;Miura M;Ichijo H;Takeda K
通讯作者：
Takeda K
影响因子：
4.5
作者：
Imai Y;Kanao T;Sawada T;Kobayashi Y;Moriwaki Y;Ishida Y;Takeda K;Ichijo H;Lu B;Takahashi R
通讯作者：
Takahashi R
DOI：
10.1083/jcb.201008084
发表时间：
2010-11-29
期刊：
The Journal of cell biology
影响因子：
--
作者：
Jin SM;Lazarou M;Wang C;Kane LA;Narendra DP;Youle RJ
通讯作者：
Youle RJ
影响因子：
64.5
作者：
Cho YS;Challa S;Moquin D;Genga R;Ray TD;Guildford M;Chan FK
通讯作者：
Chan FK
影响因子：
--
作者：
Ganesan, Sandhya;Aggarwal, Kamna;Paquette, Nicholas;Silverman, Neal
通讯作者：
Silverman, Neal