Long non-coding RNA metastasis associated in lung adenocarcinoma transcript 1 (MALAT1) interacts with estrogen receptor and predicted poor survival in breast cancer.
Long non-coding RNA metastasis associated in lung adenocarcinoma transcript 1 (MALAT1) interacts with estrogen receptor and predicted poor survival in breast cancer.
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肺腺癌转录物 1 (MALAT1) 相关的长非编码 RNA 转移与雌激素受体相互作用并预测乳腺癌的不良生存
DOI：
10.18632/oncotarget.9364
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发表时间：
2016-06-21
期刊：
影响因子：
--
通讯作者：
Wu J
中科院分区：
文献类型：
--
作者：
Huang NS;Chi YY;Xue JY;Liu MY;Huang S;Mo M;Zhou SL;Wu J
转移相关的肺腺癌转录本1 （MALAT1）是一种lncRNA，最初被认为是I期肺癌患者生存的预后参数，在包括乳腺癌在内的多种人类恶性肿瘤中上调。然而，其作用机制尚不清楚。在本研究中，我们通过检测MALAT1在mRNA水平上的表达，证实与MCF10A相比，MALAT1在大多数乳腺癌细胞系中表达上调（9/12）。在26对雌激素受体（ER）阳性的乳腺癌样本中，MALAT1的表达与邻近正常组织相比显著上调（P = 0.012）。此外，在204例乳腺癌患者中，MALAT1高表达与ER （P = 0.023）和孕激素受体（PR） （P = 0.024）阳性状态相关。进一步利用TCGA数据库分析发现，与未改变组相比，MALAT1改变组ER及其靶基因PGR和CCND1在mRNA和蛋白水平上均过表达。最后，我们验证了MALAT1在乳腺癌中的预后价值。在截断值为75%时，在多因素Cox回归模型中，MALAT1是影响er阴性患者无复发生存（RFS）的唯一独立预后因素（风险比[HR] = 2.83, 95%可信区间[CI] 1.02-7.83）。在他莫昔芬治疗的er阳性乳腺癌患者中，MALAT1过表达也与较差的RFS相关，这可能作为预测内分泌治疗敏感性的潜在生物标志物。
Metastasis associated in lung adenocarcinoma transcript 1 (MALAT1), a lncRNA that was first recognized as a prognostic parameter for patient survival of stage I lung cancer, is up-regulated in multiple human malignancies, including breast cancer. However, the mechanism of its function remained elusive. In the current study, by examining MALAT1 expression on mRNA level, we demonstrated that compared with MCF10A, MALAT1 expression was up-regulated in the majority of breast cancer cell lines (9/12). In 26 pairs of estrogen receptor (ER)-positive breast cancer samples, MALAT1 expression was significantly up-regulated compared with adjacent normal tissues (P = 0.012). Furthermore, of 204 breast cancer patients, high MALAT1 expression was associated with positive ER (P = 0.023) and progesterone receptor (PR) (P = 0.024) status. Further analysis using TCGA database revealed that ER and its target genes PGR and CCND1, were overexpressed in MALAT1 altered group compared with unaltered group, both on the mRNA and protein level. Lastly, we verified MALAT1's prognostic value in breast cancer. At the cut-off value of 75%, MALAT1 was the only independent prognostic factor of recurrence-free survival (RFS) in ER-negative patients in a multivariate Cox regression model (hazard ratio [HR] = 2.83, 95% confidence interval [CI] 1.02–7.83). MALAT1 overexpression was also associated with poor RFS in tamoxifen treated ER-positive breast cancer patients, which might serve as a potential biomarker to predict endocrine treatment sensitivity.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
影响因子：
64.8
作者：
Ellis, Matthew J.;Ding, Li;Shen, Dong;Luo, Jingqin;Suman, Vera J.;Wallis, John W.;Van Tine, Brian A.;Hoog, Jeremy;Goiffon, Reece J.;Goldstein, Theodore C.;Ng, Sam;Lin, Li;Crowder, Robert;Snider, Jacqueline;Ballman, Karla;Weber, Jason;Chen, Ken;Koboldt, Daniel C.;Kandoth, Cyriac;Schierding, William S.;McMichael, Joshua F.;Miller, Christopher A.;Lu, Charles;Harris, Christopher C.;McLellan, Michael D.;Wendl, Michael C.;DeSchryver, Katherine;Allred, D. Craig;Esserman, Laura;Unzeitig, Gary;Margenthaler, Julie;Babiera, G. V.;Marcom, P. Kelly;Guenther, J. M.;Leitch, Marilyn;Hunt, Kelly;Olson, John;Tao, Yu;Maher, Christopher A.;Fulton, Lucinda L.;Fulton, Robert S.;Harrison, Michelle;Oberkfell, Ben;Du, Feiyu;Demeter, Ryan;Vickery, Tammi L.;Elhammali, Adnan;Piwnica-Worms, Helen;McDonald, Sandra;Watson, Mark;Dooling, David J.;Ota, David;Chang, Li-Wei;Bose, Ron;Ley, Timothy J.;Piwnica-Worms, David;Stuart, Joshua M.;Wilson, Richard K.;Mardis, Elaine R.
通讯作者：
Mardis, Elaine R.
影响因子：
5.2
作者：
Xu, Chuan;Yang, Minhui;Li, Zuguo
通讯作者：
Li, Zuguo
MALAT1通过竞争性结合miR-1与cdc42诱导人乳腺癌细胞的迁移和侵袭
DOI：
10.1016/j.bbrc.2016.02.102
发表时间：
2016-03-25
影响因子：
3.1
作者：
Chou, Jinjiang;Wang, Bingyu;Xi, Tao
通讯作者：
Xi, Tao
影响因子：
7.5
作者：
Fellenberg, Joerg;Bernd, Ludger;Zahlten-Hinguranage, Anita
通讯作者：
Zahlten-Hinguranage, Anita