Visceral adiposity index (VAI) is predictive of an altered adipokine profile in patients with type 2 diabetes.
Visceral adiposity index (VAI) is predictive of an altered adipokine profile in patients with type 2 diabetes.
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DOI：
10.1371/journal.pone.0091969
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Giordano C
中科院分区：
文献类型：
--
作者：
Amato MC;Pizzolanti G;Torregrossa V;Misiano G;Milano S;Giordano C
尽管“脂肪组织功能障碍”（ATD）仍没有明确的定义，但识别脂肪分布和功能改变的临床标志物可能为早期识别心脏代谢风险状况提供必要的工具。我们的目的是评估2型糖尿病（DM2）患者各种人体测量指标[BMI、腰围（WC）、臀围（HC）、腰臀比（WHR）、体脂指数（BAI）和内脏脂肪指数（VAI）]与几种脂肪细胞因子[Visfatin、Resistin、Leptin、可溶性瘦素受体（sOB-R）、脂联素、Ghrelin、Adipsin、PAI-1、血管内皮生长因子（VEGF）、肝细胞生长因子（HGF） TNF-α、hs-CRP、IL-6、IL-18]之间的相关性。本文对91例DM2患者（年龄：65.25±6.38岁，男42例，女49例）在过去6个月稳定使用二甲双胍单药治疗（1.5-2 g/d）的患者进行了横剖面研究。评估临床、人体测量和代谢参数。采用基于Luminex的试剂盒检测血清脂肪细胞因子水平。Pearson相关分析显示，在所有调查的指标中，VAI与几乎所有分析的脂肪细胞因子[Visfatin， Resistin和hsCRP]具有显著相关性（均p<0.001）；脂联素、sOb-R、IL-6、IL-18、HGF（均p<0.010）；Ghrelin和VEGF （p<0.05）。通过两步聚类分析，确定了55例脂肪细胞因子谱变化最大的患者（ATD患者）。在ROC分析中，VAI显示所有指标中c统计量最高[0.767 (95% CI 0.66-0.84)]。我们的研究表明，在最常见的肥胖评估指标中，VAI与已知的脂肪细胞因子和心脏代谢危险血清标志物的相关性最好。尽管到目前为止，我们还远远不能明确识别ATD，但在没有明显代谢综合征的情况下，VAI将是一个简单的工具，可以清楚地反映心脏代谢风险的状况。
Although there is still no clear definition of “adipose tissue dysfunction” or ATD, the identification of a clinical marker of altered fat distribution and function may provide the needed tools for early identification of a condition of cardiometabolic risk. Our aim was to evaluate the correlations among various anthropometric indices [BMI, Waist Circumference (WC), Hip Circumference (HC), Waist/Hip ratio (WHR), Body Adiposity Index (BAI) and Visceral adiposity Index (VAI)] and several adipocytokines [Visfatin, Resistin, Leptin, Soluble leptin receptors (sOB-R), Adiponectin, Ghrelin, Adipsin, PAI-1, vascular endothelial growth factor (VEGF), Hepatocyte growth factor (HGF) TNF-α, hs-CRP, IL-6, IL-18] in patients with type 2 diabetes (DM2). Ninety-one DM2 patients (age: 65.25±6.38 years; 42 men and 49 women) in stable treatment for the last six months with metformin in monotherapy (1.5–2 g/day) were cross-sectionally studied. Clinical, anthropometric, and metabolic parameters were evaluated. Serum adipocytokine levels were assayed with Luminex based kits. At the Pearson’s correlation, among all the indices investigated, VAI showed a significant correlation with almost all adipocytokines analyzed [Visfatin, Resistin and hsCRP (all p<0.001); Adiponectin, sOb-R, IL-6, IL-18, HGF (all p<0.010); Ghrelin and VEGF (both p<0.05)]. Through a two-step cluster analysis, 55 patients were identified with the most altered adipocytokine profile (patients with ATD). At a ROC analysis, VAI showed the highest C-statistic [0.767 (95% CI 0.66–0.84)] of all the indices. Our study suggests that the VAI, among the most common indexes of adiposity assessment, shows the best correlation with the best known adipocytokines and cardiometabolic risk serum markers. Although to date we are still far from clearly identifying an ATD, the VAI would be an easy tool for clearly mirroring a condition of cardiometabolic risk, in the absence of an overt metabolic syndrome.
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影响因子：
1.9
作者：
Knowles KM;Paiva LL;Sanchez SE;Revilla L;Lopez T;Yasuda MB;Yanez ND;Gelaye B;Williams MA
通讯作者：
Williams MA
影响因子：
6.9
作者：
Bergman, Richard N.;Stefanovski, Darko;Buchanan, Thomas A.;Sumner, Anne E.;Reynolds, James C.;Sebring, Nancy G.;Xiang, Anny H.;Watanabe, Richard M.
通讯作者：
Watanabe, Richard M.
影响因子：
4.5
作者：
Amato MC;Giordano C;Pitrone M;Galluzzo A
通讯作者：
Galluzzo A
影响因子：
5.8
作者：
Ciresi, A.;Amato, M. C.;Galluzzo, C. Giordano
通讯作者：
Galluzzo, C. Giordano
影响因子：
6.1
作者：
Amato, Marco Calogero;Verghi, Monica;Giordano, Carla
通讯作者：
Giordano, Carla