Impact of low blood lead concentrations on IQ and school performance in Chinese children.
Impact of low blood lead concentrations on IQ and school performance in Chinese children.
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低血铅浓度对中国儿童的智商和学校表现的影响。
DOI：
10.1371/journal.pone.0065230
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Liu X
中科院分区：
文献类型：
--
作者：
Liu J;Li L;Wang Y;Yan C;Liu X
探讨血铅浓度与儿童智商、学习成绩的关系。参与者是来自中国金坛的1341名儿童（738名男孩和603名女孩）。在3-5岁时测定血铅浓度。采用韦氏学龄前和小学智力量表（修订版）的中文版和常模，对6岁儿童进行智商测定。在8-10岁的儿童中，学校表现通过3个主要科目（中文，数学和英语[作为外语]）的标准化城市测试进行评估。平均血铅浓度为6.43 µg/dL（SD = 2.64）。 对于血铅浓度，7.8%的儿童（n = 105）≥10.0 µg/dL，13.8%（n = 185）为8.0至<10.0 µg/dL，78.4%（n = 1051）<8.0 µg/dL。 与血铅浓度<8 µg/dL的儿童相比，血铅浓度≥8 µg/dL的儿童智商低2-3分，学校测试低5-6分。血铅浓度为8-10和≥10 µg/dL的儿童在智商或学校测试中没有显著差异。在校正儿童和家庭特征以及智商后，3-5岁时血铅浓度≥10 µg/dL与<8 µg/dL与8-10岁时学校考试成绩下降相关（中文，β = −3.54，95%CI = −6.46，−0.63;数学，β = −4.63，95%CI = −7.86，−1.40;英语，β = −4.66，95%CI = −8.09，−1.23）。 智商部分介导了血铅浓度升高和以后的学校表现之间的关系。研究结果支持儿童早期血铅浓度，即使<10 µg/dL，也会对认知发育产生长期负面影响。血铅浓度8-10 µg/dL与认知发育之间的关系需要在中国儿童和其他发展中国家儿童中进一步研究。
Examine the relationships between blood lead concentrations and children's intelligence quotient (IQ) and school performance. Participants were 1341 children (738 boys and 603 girls) from Jintan, China. Blood lead concentrations were measured when children were 3–5 years old. IQ was assessed using the Chinese version and norms of the Wechsler Preschool and Primary Scale of Intelligence – Revised when children were 6 years old. School performance was assessed by standardized city tests on 3 major subjects (Chinese, Math, and English [as a foreign language]) when children were age 8–10 years. Mean blood lead concentration was 6.43 µg/dL (SD = 2.64). For blood lead concentrations, 7.8% of children (n = 105) had ≥10.0 µg/dL, 13.8% (n = 185) had 8.0 to <10.0 µg/dL, and 78.4% (n = 1051) had <8.0 µg/dL. Compared to children with blood lead concentrations <8 µg/dL, those with blood lead concentrations ≥8 µg/dL scored 2–3 points lower in IQ and 5–6 points lower in school tests. There were no significant differences in IQ or school tests between children with blood lead concentrations groups 8–10 and ≥10 µg/dL. After adjustment for child and family characteristics and IQ, blood lead concentrations ≥10 µg/dL vs <8 µg/dL at ages 3–5 years was associated with reduced scores on school tests at age 8–10 years (Chinese, β = −3.54, 95%CI = −6.46, −0.63; Math, β = −4.63, 95%CI = −7.86, −1.40; English, β = −4.66, 95%CI = −8.09, −1.23). IQ partially mediated the relationship between elevated blood lead concentrations and later school performance. Findings support that blood lead concentrations in early childhood, even <10 µg/dL, have a long-term negative impact on cognitive development. The association between blood lead concentrations 8–10 µg/dL and cognitive development needs further study in Chinese children and children from other developing countries.
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影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
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影响因子：
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