Exercise and cancer-related fatigue in adults: a systematic review of previous systematic reviews with meta-analyses.
Exercise and cancer-related fatigue in adults: a systematic review of previous systematic reviews with meta-analyses.
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DOI：
10.1186/s12885-017-3687-5
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发表时间：
2017-10-23
期刊：
影响因子：
3.8
通讯作者：
Kelley KS
中科院分区：
文献类型：
--
作者：
Kelley GA;Kelley KS
通过荟萃分析对先前的系统性综述进行系统性综述，以确定运动（有氧运动、力量运动或两者兼而有之）对患有任何类型癌症的成年人的癌症相关疲劳（CRF）的影响。通过检索6个电子数据库和交叉引用，纳入了截至2016年7月发表的既往随机对照试验的系统性综述和荟萃分析。采用双选法和数据提取法。方法学质量采用多系统评价评估（AMSTAR）工具评估。使用随机效应模型合并的标准化平均差异（SMD）作为效应量。此外，还计算了95%预测区间（PI）、需要治疗的人数（NNT）和百分位数改善。纳入了16项研究，每项分析代表2至48个SMD效应量（平均值± SD，7 ± 8，中位数= 5）和37至3254名受试者（平均值± SD，633 ± 690，中位数= 400）。训练持续时间为3 - 52周（平均值± SD，14.6 ± 3.1，中位数= 14），频率为每周1 - 10次（平均值± SD，3.4 ± 0.8，中位数= 3），每次持续时间为10 - 120 min（平均值± SD，44.3 ± 5.5，中位数= 45）。校正后的AMSTAR评分范围为44.4%-80.0%（平均值± SD，68.8% ± 12.0%，中位数= 72.5%）。总体而言，CRF的平均SMD改善范围为-1.05至0.01，55个荟萃分析结果中有22个（52.7%）具有统计学显著性（非重叠95% CI）。当计算具有非重叠95% CI的结果的PI时，25例患者中仅3例（12%）产生了支持CRF降低的非重叠95% PI。需要治疗的数量和百分位数改善范围分别为3 - 16和4.4 - 26.4。关于运动对成人CRF的益处缺乏确定性。然而，运动似乎不会增加成年人的CRF。PROSPERO注册号CRD 42016045405。本文的在线版本（10.1186/s12885-017-3687-5）包含补充材料，可供授权用户使用。
Conduct a systematic review of previous systematic reviews with meta-analysis to determine the effects of exercise (aerobic, strength or both) on cancer-related-fatigue (CRF) in adults with any type of cancer. Systematic reviews with meta-analyses of previous randomized controlled trials published through July of 2016 were included by searching six electronic databases and cross-referencing. Dual-selection and data abstraction were conducted. Methodological quality was assessed using the Assessment of Multiple Systematic Reviews (AMSTAR) instrument. Standardized mean differences (SMD) that were pooled using random-effects models were included as the effect size. In addition, 95% prediction intervals (PI), number needed-to-treat (NNT) and percentile improvements were calculated. Sixteen studies representing 2 to 48 SMD effect sizes per analysis (mean ± SD, 7 ± 8, median = 5) and 37 to 3254 participants (mean ± SD, 633 ± 690, median = 400) were included. Length of training lasted from 3 to 52 weeks (mean ± SD, 14.6 ± 3.1, median = 14), frequency from 1 to 10 times per week (mean ± SD, 3.4 ± 0.8, median = 3), and duration from 10 to 120 min per session (mean ± SD, 44.3 ± 5.5, median = 45). Adjusted AMSTAR scores ranged from 44.4% to 80.0% (mean ± SD, 68.8% ± 12.0%, median = 72.5%). Overall, mean SMD improvements in CRF ranged from −1.05 to −0.01, with 22 of 55 meta-analytic results (52.7%) statistically significant (non-overlapping 95% CI). When PI were calculated for results with non-overlapping 95% CI, only 3 of 25 (12%) yielded non-overlapping 95% PI favoring reductions in CRF. Number needed-to-treat and percentile improvements ranged from 3 to 16 and 4.4 to 26.4, respectively. A lack of certainty exists regarding the benefits of exercise on CRF in adults. However, exercise does not appear to increase CRF in adults. PROSPERO Registration # CRD42016045405. The online version of this article (10.1186/s12885-017-3687-5) contains supplementary material, which is available to authorized users.
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DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
4.6
作者：
Bloch, S;Walter, G
通讯作者：
Walter, G
影响因子：
3.8
作者：
Brown, Justin C.;Huedo-Medina, Tania B.;Johnson, Blair T.
通讯作者：
Johnson, Blair T.
影响因子：
3.6
作者：
Ades, A. E.;Caldwell, Deborah M.;Dias, Sofia
通讯作者：
Dias, Sofia
影响因子：
22.4
作者：
COHEN, J
通讯作者：
COHEN, J