A cohort study of the impact of tooth loss and periodontal disease on respiratory events among COPD subjects: modulatory role of systemic biomarkers of inflammation.
A cohort study of the impact of tooth loss and periodontal disease on respiratory events among COPD subjects: modulatory role of systemic biomarkers of inflammation.
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DOI：
10.1371/journal.pone.0068592
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Offenbacher S
中科院分区：
文献类型：
--
作者：
Barros SP;Suruki R;Loewy ZG;Beck JD;Offenbacher S
在COPD患者中，致死性和非致死性呼吸系统相关事件受年龄、呼吸系统疾病严重程度和合并症的影响。分析无牙、牙周病和全身炎症生物标志物对COPD受试者发生严重致死性和非致死性炎症相关事件的影响。病例来自社区研究中的牙动脉粥样硬化风险。无牙症被定义为没有任何天然牙齿或种植体的研究参与者。有一颗或多颗天然牙齿的参与者（包括11，378名受试者）作为有牙齿的受试者进行研究。使用由疾病控制中心/美国牙周病协会联合工作组发布的共识定义来确定有齿个体中的牙周病状态。调整后的风险模型被开发来评估无牙症/牙周病和COPD相关事件之间的关系。然后按GOLD阶段I、II和III/IV对模型进行分层。还评价了血清生物标志物以探索全身炎症的影响。口腔健康状况与COPD相关事件之间存在统计学显著相关性，即使调整了高血压，吸烟和糖尿病等条件。被诊断患有COPD的无牙个体比有牙齿且口腔具有健康牙周状态的个体具有更高的发病率，并且具有更大的COPD相关事件（住院和死亡）的风险。然而，对于那些在基线时被分类为GOLD III/IV的研究参与者来说，无牙并没有传递出COPD相关事件的额外风险。最后，我们发现血清IL-6水平在最高两个四分位数的个体发生COPD相关事件的风险更高。这些结果表明，在调整潜在混杂因素后，COPD相关事件的风险可能归因于缺牙和血清IL-6水平升高。
In COPD patients, fatal and non-fatal respiratory-related events are influenced by age, severity of respiratory disease, and comorbidities. Analyze the effects of edentulism, periodontal disease and systemic biomarkers of inflammation on the occurrence of serious fatal and non-fatal respiratory-related events among subjects with COPD. Cases were identified from Dental Atherosclerosis Risk in Communities study. Edentulism was defined as study participants without any natural teeth or implants. Participants with one or more natural teeth (comprising 11,378 subjects) were studied as dentate subjects. Periodontal disease status among dentate individuals was determined using the consensus definitions published by the joint Center for Disease Control/American Association of Periodontology working group). Adjusted Hazard Models are developed to evaluate the relationship between edentulism/periodontal disease and COPD Related Events. Models were then stratified by GOLD Stage I, II and III/IV. Serum biomarkers were also evaluated to explore the effect of systemic inflammation. A statistically significant association was found between oral health status and COPD-related events, even adjusting for conditions such as hypertension, smoking and diabetes. Edentulous individuals who had been diagnosed with COPD had a higher incidence and were at greater risk of having a COPD related event (hospitalization and death) than individuals who had teeth and whose mouths had healthy periodontal status. However, being edentulous did not convey excess risk for COPD-related events for those study participants who were classified as GOLD III/IV at baseline. Finally, we showed that individuals who had levels of serum IL-6 in the highest two quartiles were at even higher risk for COPD-related events. These findings suggest that the risk for COPD-related events after adjusting for potential confounders may be attributable to both edentulism and elevated serum IL-6 levels.
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影响因子：
4.3
作者：
Koromantzos, Panagiotis A.;Makrilakis, Konstantinos;Madianos, Phoebus N.
通讯作者：
Madianos, Phoebus N.
影响因子：
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作者：
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DOI：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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作者：
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影响因子：
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作者：
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