Paternal prescription medication before conception: A retrospective cohort study of all births in Denmark 1997-2017.
Paternal prescription medication before conception: A retrospective cohort study of all births in Denmark 1997-2017.
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DOI：
10.1177/1403494820987468
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发表时间：
2021-12
影响因子：
3.4
通讯作者：
Eisenberg ML
中科院分区：
文献类型：
--
作者：
Wensink MJ;Rizzi S;Jensen TK;Skakkebaek NE;Lu Y;Lindahl-Jacobsen R;Eisenberg ML
研究在怀孕前的几个月里父亲们被开了什么药。丹麦国家登记处的回顾性队列研究，包括1997-2017年丹麦的所有出生（130万例出生）。时间趋势和绝对水平的父亲处方药在怀孕前6个月进行了评估。虽然对所有药物进行了检查（N=1335），但我们重点关注主要药物组，随着时间的推移使用量增加的药物，以及先前证据表明可能影响精子质量的药物。在研究期间，平均处方数量增加（从0.75张处方增加到0.82张）。多药（3个或更多处方）从不到8%增加到10%的父亲。止痛药、质子泵抑制剂、选择性5-羟色胺再摄取抑制剂和一些吸入剂在过去20年中的使用都显著增加。父亲用药对后代造成的潜在伤害可能是一个越来越严重的问题。随着父亲药物暴露的增加，有必要检查代际效应，例如对重大出生缺陷的任何影响。
To study what medication fathers are being prescribed in the months preceding conception. Retrospective cohort study of Danish national registries, comprising all births in Denmark 1997-2017 (1.3 million births). Time trends and absolute levels of paternal prescription medication in the 6 months prior to conception were assessed. While all medications were examined (N=1335), we focus on main medication groups, medications that have increased in use over time, and medications for which previous evidence suggest they may affect sperm quality. The average number of prescriptions increased over the study period (from 0.75 prescriptions to 0.82 per birth). Polypharmacy (3 or more prescriptions) increased from less than 8%, to 10% of fathers. Pain medication, proton-pump inhibitors, selective serotonin reuptake inhibitors and some inhalants all increased markedly in use over the past 20 years. Potential harm to the offspring done by paternal medication may present an increasing problem. As paternal medication exposure is increasing, examination of generational effects, such as any effects on major birth defects, is necessary.
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DOI：
10.5534/wjmh.2017.35.2.59
发表时间：
2017-08
期刊：
The world journal of men's health
影响因子：
--
作者：
Guo D;Li S;Behr B;Eisenberg ML
通讯作者：
Eisenberg ML
影响因子：
2.6
作者：
Koyuncu, H.;Serefoglu, E. C.;Sarica, K.
通讯作者：
Sarica, K.
影响因子：
158.5
作者：
Louik, Carol;Lin, Angela E.;Mitchell, Allen A.
通讯作者：
Mitchell, Allen A.
影响因子：
3.8
作者：
Elnazer, Hesham Y.;Baldwin, David S.
通讯作者：
Baldwin, David S.
影响因子：
13.6
作者：
Bliddal, Mette;Broe, Anne;Langhoff-Roos, Jens
通讯作者：
Langhoff-Roos, Jens