The circadian pattern of cardiac autonomic modulation in a middle-aged population.
The circadian pattern of cardiac autonomic modulation in a middle-aged population.
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DOI：
10.1007/s10286-010-0112-4
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发表时间：
2011-06
影响因子：
5.8
通讯作者：
Liao, Duanping
中科院分区：
文献类型：
--
作者：
Li, Xian;Shaffer, Michele L.;Rodriguez-Colon, Sol;He, Fan;Wolbrette, Deborah L.;Alagona, Peter, Jr.;Wu, Chuntao;Liao, Duanping
研究一般人群心脏自主调节（CAM）的昼夜节律模式及其特征。我们使用高分辨率12导联霍尔特心电图（Holter ECG）获得了115名社区居民非吸烟者的24小时搏动RR数据。我们对每个5分钟时段的正常心率变异性（HRV）进行分析，得到高（HF; 0.15-0.40 Hz）和低（LF; 0.04-0.15 Hz）频率功率、RR区间标准差（SDNN）和相邻RR区间平方差和均值的平方根（RMSSD）的时间特异性HRV指数。对于每个个体，我们将特定区段的HRV数据拟合为余弦周期函数，并估计3个个体水平的余弦函数参数来量化昼夜变化：平均值(M)，振幅(a)和顶相（θ）。然后，我们使用随机效应荟萃分析来总结M、a和θ及其95%置信区间（CI）。平均年龄56岁（SD 8），女性63%，白人76%。log HF的M、A和θ (95%CI)均值分别为3.59 (3.43 ~ 3.76)ms2、0.61 (0.54 ~ 0.68)ms2和3:10 (2:25 ~ 3:55)AM， RMSSD的M、A和θ (95%CI)均值分别为22.3 (20.5 ~ 24.1)ms、6.5 (5.4 ~ 7.5)ms和3:45 (2:55 ~ 4:35)AM。年龄越大，HRV平均值越低。雄性的振荡幅度比雌性大。LF/HF的顶期女性比男性早，年轻人比老年人早。HRV的3个余弦参数可以量化CAM的昼夜节律模式，这些参数与年龄和性别相关。
To examine the circadian pattern of cardiac autonomic modulation (CAM) and its attributes in general population. We obtained 24-h beat-to-beat RR data using a high resolution 12-lead Holter ECG in a community-dwelling sample of 115 non-smokers. We performed heart rate variability (HRV) analysis on the normal RRs from each 5-min segment to obtain time-specific HRV indices: high (HF; 0.15–0.40 Hz) and low (LF; 0.04–0.15 Hz) frequency powers, standard deviation of RR intervals (SDNN), and the square root of the mean of the sum of the squared differences of the adjacent RR intervals (RMSSD). For each individual, we fit the segment-specific HRV data to a cosine periodic function, and estimated 3 individual-level cosine function parameters to quantify the circadian variation: the mean (M), amplitude (A), and acrophase (θ). We then used a random-effects meta-analysis to summarize the M, A, and θ, and their 95% confidence intervals (CI). The mean age was 56 (SD 8) years, with 63% female and 76% white. The averages of M, A and θ (95%CI) of log HF were 3.59 (3.43–3.76) ms2, 0.61 (0.54–0.68) ms2, and 3:10 (2:25–3:55) AM, respectively, and that of RMSSD were 22.3 (20.5–24.1) ms, 6.5 (5.4–7.5) ms, 3:45 (2:55–4:35) AM, respectively. Older age is associated with lower mean of HRV. Males have higher oscillation amplitude than females. The acrophase of LF/HF was earlier in females than in males, and in younger individuals than in older individuals. The circadian pattern of CAM can be quantified by 3 cosine parameters of HRV, which are correlated with age and gender.
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影响因子：
--
作者：
POMERANZ, B;MACAULAY, RJB;BENSON, H
通讯作者：
BENSON, H
影响因子：
56.9
作者：
AKSELROD, S;GORDON, D;COHEN, RJ
通讯作者：
COHEN, RJ
影响因子：
37.8
作者：
Dekker, JM;Crow, RS;Schouten, EG
通讯作者：
Schouten, EG
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
10.8
作者：
Bernardi, L;Valle, F;Sleight, P
通讯作者：
Sleight, P