Clinical Features and Outcome of Low and High Corticosteroids in Admitted COVID-19 Patients.
Clinical Features and Outcome of Low and High Corticosteroids in Admitted COVID-19 Patients.
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入院的Covid-19患者中低皮质类固醇的临床特征和高层皮质类固醇的结果。
DOI：
10.2991/jegh.k.210521.001
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发表时间：
2021-09
影响因子：
7.3
通讯作者：
Alrowis A
中科院分区：
文献类型：
--
作者：
AlBahrani S;Al-Tawfiq JA;Jebakumar AZ;Alghamdi M;Zakary N;Seria M;Alrowis A
引言：对于2019冠状病毒病（COVID-19）感染，没有特异性抗病毒疗法。在这里，我们比较了接受不同剂量类固醇与没有类固醇的严重和危重COVID-19患者。方法：我们回顾性研究了接受低剂量或高剂量皮质类固醇治疗的COVID-19患者，并与未接受类固醇治疗的患者进行了比较。结果如下：研究期间（2020年6月至8月）纳入169名COVID-19患者，其中39. 1%为女性，60. 9%为男性，平均年龄为53. 1岁。病例分布如下：高剂量39例（23.1%），低剂量54例（32.0%），无类固醇76例（45.5%）。在所有患者中，31例（18.3%）进入重症监护室（ICU），9例（5.3%）需要插管，52例（30.8%）无合并症。不同组之间的平均年龄没有差异。然而，接受类固醇治疗的患者更有可能具有较高的序贯器官衰竭评估（SOFA）评分（低剂量、高剂量类固醇和无类固醇组分别为0.37 ± 0.68、0.36 ± 0.67和0.04 ± 0.34（p = 0.001））。考克斯回归不可能，因为死亡率非常低（3/169; 1.78%），并且没有一种多变量方法是可能的。然而，住院时间（LOS）和ICU LOS存在显着差异。结论：考克斯回归是不可能的，因为死亡率非常低（1.78%），并且由于模型不会收敛，因此任何多变量方法都是不可能的。然而，仅在t检验中，插管与死亡风险相关。
Introduction: There is no specific anti-viral therapies for 2019 Coronavirus Diseases (COVID-19) infection. Here, we compared patients receiving steroids at different dosages versus no steroids in severe and critical COVID-19 patients. Methods: We retrospectively studied COVID-19 patients who received low-dose or high-dose corticosteroid therapy compared to no steroid. Results: The study period, June–August 2020, included 169 patients with COVID-19 were included and there were 39.1% female and 60.9% male with an average age of 53.1 years. The distribution of cases was as follows: high-dose 39 (23.1%), low-dose 54 (32.0%), and no steroid 76 (45.5%). Of all the patients, Intensive Care Unit (ICU) admission was for 31 (18.3%), nine (5.3%) required intubation, and 52 (30.8%) had no comorbidities. There is no difference in the mean age between the different groups. However, those being treated with steroid were more likely to have a high sequential organ failure assessment (SOFA) score (0.37 ± 0.68, 0.36 ± 0.67 and 0.04 ± 0.34, for low-dose, high-dose steroid and no steroid groups, respectively (p = 0.001). Cox regression was not possible as the mortality rate was very low (3/169; 1.78%) and none of the multivariate methods would be possible. However, there was a significant difference in the hospital Length of stay (LOS) and the ICU LOS. Conclusion: Cox regression was not possible as the mortality rate was very low (1.78%) and none of the multivariate methods would be possible as the model will not converge. However, in t-test only, intubation was associated risk of mortality.
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影响因子：
12
作者：
Al-Tawfiq JA;Sattar A;Al-Khadra H;Al-Qahtani S;Al-Mulhim M;Al-Omoush O;Kheir HO
通讯作者：
Kheir HO
影响因子：
6.7
作者：
Al-Omari A;Alhuqbani WN;Zaidi ARZ;Al-Subaie MF;AlHindi AM;Abogosh AK;Alrasheed AK;Alsharafi AA;Alhuqbani MN;Salih S;Alhedaithy MA;Abdulqawi R;Ismail AF;Alhumaid S;Hamdan N;Saad F;Olhaye FA;Eltahir TA;Alomari M;Alshehery M;Yassiri A;Al-Tawfiq JA;Al Mutair A
通讯作者：
Al Mutair A
影响因子：
12
作者：
Tirupathi R;Muradova V;Shekhar R;Salim SA;Al-Tawfiq JA;Palabindala V
通讯作者：
Palabindala V
东部沙特阿拉伯省无症状和有症状的Covid-19患者的临床特征。
影响因子：
6.7
作者：
AlJishi JM;Alhajjaj AH;Alkhabbaz FL;AlAbduljabar TH;Alsaif A;Alsaif H;Alomran KS;Aljanobi GA;Alghawi Z;Alsaif M;Al-Tawfiq JA
通讯作者：
Al-Tawfiq JA
DOI：
10.1073/pnas.2005615117
发表时间：
2020-05-19
影响因子：
11.1
作者：
Xu, Xiaoling;Han, Mingfeng;Wei, Haiming
通讯作者：
Wei, Haiming