Urinary polycyclic aromatic hydrocarbons and childhood obesity: NHANES (2001-2006).
Urinary polycyclic aromatic hydrocarbons and childhood obesity: NHANES (2001-2006).
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DOI：
10.1289/ehp.1307234
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发表时间：
2014-03
影响因子：
10.4
通讯作者：
Buser MC
中科院分区：
文献类型：
--
作者：
Scinicariello F;Buser MC
背景：多环芳烃(PAHs)是已知的致癌物质和可疑的内分泌干扰物。产前暴露于多环芳烃与儿童早期肥胖有关。目的：我们研究了儿童和青少年中尿PAH代谢产物与肥胖结局[体重指数(BMI)z评分、腰围(WC)和肥胖率]之间的关系。方法：我们对参加2001-2006年国民健康与营养调查的3189名6-19岁的人进行了全样本分析。我们用多元线性回归和Logistic回归分析了BMI、腰围和肥胖与单次尿多环芳烃化合物浓度和多环芳烃总量之间的关系。此外，分析按发展阶段[即儿童(6-11岁)和青少年(12-19岁)]分层。结果：BMI z-Score、WC、肥胖与多环芳烃的分子质量总和、萘代谢物的总和呈正相关。在6-11岁的儿童中，大多数关联随着暴露的四分位数的增加而单调增加，而在青少年(12-19岁)中，剂量-反应趋势不太一致。在这两个年龄组中，总的多环芳烃和总的萘代谢物都与超重无关，而且几乎没有证据表明结果与单独的多环芳烃之间存在关联。结论：在6-11岁的儿童中，尿总多环芳烃代谢物和萘代谢物与较高的BMI、WC和肥胖症相关，在青少年中呈正相关，但一致性较差。引文：Scinicariello F，Buser MC。2014年。尿多环芳烃与儿童肥胖：NHANES(2001-2006)。环境健康展望122:299–303； http://dx.doi.org/10.1289/ehp.1307234
Background: Polycyclic aromatic hydrocarbons (PAHs) are known carcinogens and suspected endocrine disruptors. Prenatal exposure to PAHs has been associated with obesity in early childhood. Objective: We examined the association of urinary PAH metabolites with adiposity outcomes [body mass index (BMI) z-score, waist circumference (WC), and rate of obesity] in children and adolescents. Methods: We performed whole-sample analyses of 3,189 individuals 6–19 years of age who participated in the 2001–2006 National Health and Nutrition Examination Survey. We performed multivariate linear and logistic regression to analyze the association of BMI z-score, WC, and obesity with concentrations of single urinary PAH compounds and the sum of PAHs. Furthermore, the analyses were stratified by developmental stage [i.e., children (6–11 years) and adolescents (12–19 years)]. Results: BMI z-score, WC, and obesity were positively associated with the molecular mass sum of the PAHs and the total sum of naphthalene metabolites. Most associations increased monotonically with increasing quartiles of exposure among children 6–11 years of age, whereas dose–response trends were less consistent for adolescents (12–19 years of age). Neither total PAHs nor total naphthalene metabolites were associated with overweight in either age group, and there was little evidence of associations between the outcomes and individual PAHs. Conclusions: Total urinary PAH metabolites and naphthalene metabolites were associated with higher BMI, WC, and obesity in children 6–11 years of age, with positive but less consistent associations among adolescents. Citation: Scinicariello F, Buser MC. 2014. Urinary polycyclic aromatic hydrocarbons and childhood obesity: NHANES (2001–2006). Environ Health Perspect 122:299–303; http://dx.doi.org/10.1289/ehp.1307234
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影响因子：
10.4
作者：
Choi H;Rauh V;Garfinkel R;Tu Y;Perera FP
通讯作者：
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影响因子：
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通讯作者：
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DOI：
10.1016/0022-4731(87)90303-7
发表时间：
1987-01-01
影响因子：
4.1
作者：
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通讯作者：
LIAO, ST