Metabolic syndrome and changes in body fat from a low-fat diet and/or exercise randomized controlled trial.
Metabolic syndrome and changes in body fat from a low-fat diet and/or exercise randomized controlled trial.
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DOI：
10.1038/oby.2009.304
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发表时间：
2010-03
期刊：
影响因子：
6.9
通讯作者：
Young, Deborah R.
中科院分区：
文献类型：
--
作者：
Camhi, Sarah M.;Stefanick, Marcia L.;Katzmarzyk, Peter T.;Young, Deborah R.
很难通过生活方式干预来确定与代谢综合征 (MetS) 变化相关的成功组成部分：体重减轻、行为改变或组合。本研究的目的是确定低脂饮食和运动单独或联合进行的体重稳定随机对照试验对 MetS 的影响。低密度脂蛋白胆固醇 (LDL-C) 升高和高密度脂蛋白胆固醇 (HDL-C) 降低的男性 (n = 179) 和绝经后女性 (n = 149) 被随机分为一项为期 1 年、体重稳定的试验，有四个治疗组：对照组 (C)、饮食组 (D)、运动组 (E) 或饮食加运动组 (D+E)。 MetS 使用连续评分来定义。使用协方差分析比较各组之间 MetS 评分 (ΔMetS) 的变化，按性别分层并使用两个模型，以基线和体脂百分比 (ΔBF) 变化作为协变量。在男性中，D 相对于 C (P = 0.04)、D+E 相对于 C (P = 0.0002) 以及 D+E 相对于 E (P = 0.02) 的 ΔMetS 较高。对于女性，D 相对于 C (P = 0.045)、E 相对于 C (P = 0.02) 和 D+E 相对于 C (P = 0.004) 的 ΔMetS 更大。调整 ΔBF 后，组间的所有差异均减弱且不再显着。对于男性 (P < 0.0001) 和女性 (P = 0.004)，ΔMetS 与 ΔBF 相关。调整 ΔBF 后，单独低脂饮食和结合运动对 MetS 没有影响。低脂饮食和/或增加体力活动导致代谢综合征的关键因素似乎是体内脂肪的减少。
It is difficult to identify the successful component(s) related to changes in metabolic syndrome (MetS) from lifestyle interventions: the weight loss, the behavior change, or the combination. The purpose of this study is to determine the effects of a weight-stable randomized controlled trial of low-fat diet and exercise, alone and in combination, on MetS. Men (n = 179) and postmenopausal women (n = 149) with elevated low-density lipoprotein cholesterol (LDL-C) and low high-density lipoprotein cholesterol (HDL-C) were randomized into a 1-year, weight-stable trial with four treatment groups: control (C), diet (D), exercise (E), or diet plus exercise (D+E). MetS was defined using a continuous score. Changes in MetS score (ΔMetS) were compared between groups using analysis of covariance, stratified by gender and using two models, with and without baseline and change in percent body fat (ΔBF) as a covariate. In men, ΔMetS was higher for D vs. C (P = 0.04), D+E vs. C (P = 0.0002), and D+E vs. E (P = 0.02). For women, ΔMetS was greater for D vs. C (P = 0.045), E vs. C (P = 0.02), and D+E vs. C (P = 0.004). After adjusting for ΔBF, all differences between groups were attenuated and no longer significant. ΔMetS were associated with ΔBF for both men (P < 0.0001) and women (P = 0.004). After adjustment for ΔBF, low-fat diet alone and in combination with exercise had no effect on MetS. The key component for MetS from low-fat diet and/or increased physical activity appears to be body fat loss.
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