Comparing different operationalizations of allostatic load measured in mid-life and their patterning by race and cumulative life course socioeconomic status.
Comparing different operationalizations of allostatic load measured in mid-life and their patterning by race and cumulative life course socioeconomic status.
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DOI：
10.1016/j.psyneuen.2022.105689
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发表时间：
2022-05
影响因子：
3.7
通讯作者：
Factor-Litvak P
中科院分区：
文献类型：
--
作者：
Kezios KL;Suglia SF;Doyle DM;Susser E;Bradwin G;Cirillo P;Cohn B;Link B;Factor-Litvak P
Since its conceptualization, there has been a lack of consensus on the best way to operationalize allostatic load (AL). As a marker of the cumulative, physiological wear and tear on the body resulting from chronic exposure to stressors, it follows that AL should be higher among people who have faced more stressful life experiences. Thus, the purpose of this study was to construct AL scores using different operationalizations and, as a measure of construct validity, compare whether each construction produced expected disparities in AL by race and a composite socioeconomic status (SES) variable which accounts for measures over the life course; we also explored differences by sex. We conducted the study in a sample of 45–52-year-old offspring from the Child Health and Development Studies, a longitudinal birth cohort established in the early 1960s. AL scores were constructed in 6 different ways and included 10 biomarkers from inflammatory, neuroendocrine, cardiovascular, and metabolic systems. Our main approach to constructing AL was to sum across high-risk biomarker quartiles, correct for medication use, and use sex-specific high-risk quartiles for specific biomarkers. Alternative constructions did not use sex-specific quartiles and/or weighted biomarkers within subsystems and/or did not correct for medication use. We estimated differences in AL scores by race, SES, sex and their pairwise interactions. All constructions of AL, including the main approach, produced expected disparities by race (higher scores for Black vs. non-Black participants) and life course SES (higher scores for low vs. high SES participants). However, disparities by sex only emerged when the AL score was constructed via approaches that did not use sex-specific high-risk quartiles; for these alternative constructions, overall, female participants had higher AL scores than male participants and Black female participants had the highest AL scores in the sample. For most constructions, the pairwise interaction between sex and SES, showed a stronger disparity in AL scores between low and high-SES female compared with low- and high-SES male participants; this suggests that high life course SES may be more important for female (in terms of lowering AL) than male participants. In conclusion, our results suggest that the basic AL concept is consistently expressed in different operationalizations, making it an especially useful and robust tool for understanding disparities by race and SES.
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影响因子：
2.3
作者：
Buckwalter JG;Castellani B;McEwen B;Karlamangla AS;Rizzo AA;John B;O'Donnell K;Seeman T
通讯作者：
Seeman T
影响因子：
2.4
作者：
McEwen, BS
通讯作者：
McEwen, BS
DOI：
10.1080/13548500500429338
发表时间：
2007-01-01
期刊：
Psychology, health & medicine
影响因子：
--
作者：
Clark, Michael S;Bond, Malcolm J;Hecker, Jane R
通讯作者：
Hecker, Jane R
影响因子：
37.8
作者：
Benjamin, Emelia J.;Virani, Salim S.;Muntner, Paul
通讯作者：
Muntner, Paul
影响因子：
3.5
作者：
Chyu, Laura;Upchurch, Dawn M.
通讯作者：
Upchurch, Dawn M.