Differential expression of voltage-gated sodium channels in afferent neurons renders selective neural block by ionic direct current.
Differential expression of voltage-gated sodium channels in afferent neurons renders selective neural block by ionic direct current.
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DOI：
10.1126/sciadv.aaq1438
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发表时间：
2018-04
期刊：
影响因子：
13.6
通讯作者：
Fridman G
中科院分区：
文献类型：
--
作者：
Yang F;Anderson M;He S;Stephens K;Zheng Y;Chen Z;Raja SN;Aplin F;Guan Y;Fridman G
研究人员研究了使用离子直流电来颠倒标准的神经刺激招募顺序。在神经调节和神经假体领域，大直径神经纤维具有低阈值，而小直径神经纤维具有高阈值的断言在神经调节和神经假体领域几乎是公理的。与用来诱发动作电位的短脉冲不同，长时间的离子直流电已被证明可以阻断神经活动。我们认为，决定神经对直流电流阻断敏感性的主要因素不是轴突的大小，而是其神经膜上普遍存在的电压门控钠通道的类型。根据电压门控性钠通道在周围神经不同类型神经元中表达的不同，我们假设小直径的伤害性感受纤维可能优先被阻断。我们展示了一个计算模型和体内神经生理学实验的结果，这些结果为这一新现象提供了实验验证。
Researchers investigate the use of ionic direct current to reverse the standard neural stimulation recruitment order. The assertion that large-diameter nerve fibers have low thresholds and small-diameter fibers have high thresholds in response to electrical stimulation has been held in a nearly axiomatic regard in the field of neuromodulation and neuroprosthetics. In contrast to the short pulses used to evoke action potentials, long-duration ionic direct current has been shown to block neural activity. We propose that the main determinant of the neural sensitivity to direct current block is not the size of the axon but the types of voltage-gated sodium channels prevalent in its neural membrane. On the basis of the variants of voltage-gated sodium channels expressed in different types of neurons in the peripheral nerves, we hypothesized that the small-diameter nociceptive fibers could be preferentially blocked. We show the results of a computational model and in vivo neurophysiology experiments that offer experimental validation of this novel phenomenon.
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影响因子：
4.3
作者：
Balbi, Pietro;Massobrio, Paolo;Kotaleskim, Jeanette Hellgren
通讯作者：
Kotaleskim, Jeanette Hellgren
影响因子：
1.7
作者：
Fjell, J;Hjelmström, P;Black, JA
通讯作者：
Black, JA
影响因子：
64.5
作者：
Basbaum AI;Bautista DM;Scherrer G;Julius D
通讯作者：
Julius D
DOI：
10.1016/s0169-328x(96)00163-5
发表时间：
1996-12-31
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Black, JA;DibHajj, S;Waxman, SG
通讯作者：
Waxman, SG
DOI：
10.1109/tnsre.2013.2245423
发表时间：
2013-03
期刊：
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
影响因子：
--
作者：
Fridman GY;Della Santina CC
通讯作者：
Della Santina CC