Biological embedding of early trauma: the role of higher prefrontal synaptic strength.
Biological embedding of early trauma: the role of higher prefrontal synaptic strength.
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DOI：
10.1080/20008066.2023.2246338
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发表时间：
2023
影响因子：
5
通讯作者：
Abdallah, Chadi
中科院分区：
文献类型：
--
作者：
Tamman, Amanda;Jiang, Lihong;Averill, Christopher;Mason, Graeme;Averill, Lynnette;Abdallah, Chadi
关键词：
背景：早期创伤预示着心理和身体健康状况不佳。谷氨酸能突触过程为理解这种关系提供了一条途径，因为谷氨酸含量丰富，并参与了奖赏和压力敏感性、情绪和学习。创伤引起的谷氨酸能兴奋毒性可能改变神经可塑性和接近/回避倾向，增加精神障碍的风险。研究检查了上游或下游的影响，而不是体内的谷氨酸能突触过程，限制了对创伤如何影响大脑的理解。目的：在一项使用先前发表的数据集的先导性研究中，我们在接受碳-13(13C-MRS)磁共振波谱的最大人类样本之一中，检验了早期创伤与体内突触强度的拟议测量方法之间的关联。受试者为18名健康对照和16名创伤后应激障碍患者(男、女)。方法：用神经元氧化能量产生与谷氨酸神经递质循环的比值--每周期能量(EPC)作为谷氨酸能突触强度的指标。结果：在创伤后应激障碍患者中，早期创伤与EPC呈正相关，而在健康对照组中则不相关。突触强度的增加与行为抑制的减少有关，对于那些具有更高的EPC的人来说，EPC显示出更强的奖赏反应性和早期创伤之间的关联。结论：在已知的进行13C MRS的最大人类样本中，我们表明早期创伤与EPC呈正相关，EPC是突触强度的直接衡量标准。我们的研究结果对被认为影响突触可塑性的药物治疗具有指导意义，如氯胺酮和裸盖菇素。突触连接强度的异常与创伤和创伤相关疾病有关，但没有直接检查。我们使用磁共振波谱来研究早期创伤和体内突触强度测量之间的联系。对于创伤后应激障碍患者，随着早期创伤严重程度的增加，突触强度增加，突触强度增加，突显了被认为改变创伤相关障碍突触连接的治疗方法的潜力。
Background: Early trauma predicts poor psychological and physical health. Glutamatergic synaptic processes offer one avenue for understanding this relationship, given glutamate’s abundance and involvement in reward and stress sensitivity, emotion, and learning. Trauma-induced glutamatergic excitotoxicity may alter neuroplasticity and approach/avoidance tendencies, increasing risk for psychiatric disorders. Studies examine upstream or downstream effects instead of glutamatergic synaptic processes in vivo, limiting understanding of how trauma affects the brain. Objective: In a pilot study using a previously published data set, we examine associations between early trauma and a proposed measure of synaptic strength in vivo in one of the largest human samples to undergo Carbon-13 (13C MRS) magnetic resonance spectroscopy. Participants were 18 healthy controls and 16 patients with PTSD (male and female). Method: Energy per cycle (EPC), which represents the ratio of neuronal oxidative energy production to glutamate neurotransmitter cycling, was generated as a putative measure of glutamatergic synaptic strength. Results: Results revealed that early trauma was positively correlated with EPC in individuals with PTSD, but not in healthy controls. Increased synaptic strength was associated with reduced behavioural inhibition, and EPC showed stronger associations between reward responsivity and early trauma for those with higher EPC. Conclusion: In the largest known human sample to undergo 13C MRS, we show that early trauma is positively correlated with EPC, a direct measure of synaptic strength. Our study findings have implications for pharmacological treatments thought to impact synaptic plasticity, such as ketamine and psilocybin. Abnormalities in the strength of synaptic connections have been implicated in trauma and trauma-related disorders but not directly examined. We used magnetic resonance spectroscopy to investigate the association between early trauma and an in vivo measure of synaptic strength. For people with posttraumatic stress disorder, as early trauma severity increased, synaptic strength increased, highlighting the potential for treatments thought to change synaptic connections in trauma-related disorders.
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影响因子：
13.5
作者：
Abdallah CG;Sanacora G;Duman RS;Krystal JH
通讯作者：
Krystal JH
DOI：
10.1016/j.euroneuro.2020.03.015
发表时间：
2020-06
期刊：
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
影响因子：
--
作者：
Averill LA;Abdallah CG;Fenton LR;Fasula MK;Jiang L;Rothman DL;Mason GF;Sanacora G
通讯作者：
Sanacora G
影响因子：
2.9
作者：
Foster, TC;Gagne, J;Massicotte, G
通讯作者：
Massicotte, G
影响因子：
2.5
作者：
Averill LA;Purohit P;Averill CL;Boesl MA;Krystal JH;Abdallah CG
通讯作者：
Abdallah CG
DOI：
10.1016/j.euroneuro.2015.04.025
发表时间：
2015-08
期刊：
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
影响因子：
--
作者：
Abdallah CG;Jackowski A;Sato JR;Mao X;Kang G;Cheema R;Coplan JD;Mathew SJ;Shungu DC
通讯作者：
Shungu DC