CD146 is a Novel ANGPTL2 Receptor that Promotes Obesity by Manipulating Lipid Metabolism and Energy Expenditure.
CD146 is a Novel ANGPTL2 Receptor that Promotes Obesity by Manipulating Lipid Metabolism and Energy Expenditure.
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CD146 是一种新型 ANGPTL2 受体，可通过操纵脂质代谢和能量消耗来促进肥胖
DOI：
10.1002/advs.202004032
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Bu P
中科院分区：
文献类型：
--
作者：
Wu Z;Liu J;Chen G;Du J;Cai H;Chen X;Ye G;Luo Y;Luo Y;Zhang L;Duan H;Liu Z;Yang S;Sun H;Cui Y;Sun L;Zhang H;Shi G;Wei T;Liu P;Yan X;Feng J;Bu P
肥胖及其相关并发症对人类健康构成越来越大的威胁;然而，靶向肥胖相关膜受体尚未阐明。在这里，膜受体CD 146被证明在肥胖症中发挥重要作用。特别是，CD 146作为血管生成素样蛋白2（ANGPTL 2）的新脂肪受体，被认为作用于内皮细胞以激活脂肪炎症。ANGPTL 2与CD 146结合以激活cAMP反应元件结合蛋白（CREB），然后在脂肪生成和脂肪炎症期间上调CD 146。CD 146存在于前脂肪细胞和成熟脂肪细胞中，在那里它由其配体ANGPTL 2和半乳糖凝集素-1介导。在前脂肪细胞中，CD 146消融抑制脂肪形成，而成熟脂肪细胞中CD 146的缺失抑制脂质积累并增加能量消耗。此外，抗CD 146抗体通过破坏CD 146与其配体之间的相互作用来抑制肥胖。总之，这些发现表明ANGPTL 2通过CD 146直接影响脂肪细胞以促进肥胖，这表明CD 146可以成为治疗肥胖的潜在靶点。膜受体CD 146是一种新型ANGPTL 2受体，可促进肥胖和胰岛素抵抗。通过与ANGPTL 2和galectin-1相互作用，CD 146增强脂肪生成和脂肪生成，同时抑制FAO和BAT产热。此外，通过敲除CD 146或使用抗CD 146抗体破坏CD 146及其配体之间的相互作用可以预防肥胖及其相关并发症。
Obesity and its related complications pose an increasing threat to human health; however, targetable obesity‐related membrane receptors are not yet elucidated. Here, the membrane receptor CD146 is demonstrated to play an essential role in obesity. In particular, CD146 acts as a new adipose receptor for angiopoietin‐like protein 2 (ANGPTL2), which is thought to act on endothelial cells to activate adipose inflammation. ANGPTL2 binds to CD146 to activate cAMP response element‐binding protein (CREB), which then upregulates CD146 during adipogenesis and adipose inflammation. CD146 is present in preadipocytes and mature adipocytes, where it is mediated by its ligands ANGPTL2 and galectin‐1. In preadipocytes, CD146 ablation suppresses adipogenesis, whereas the loss of CD146 in mature adipocytes suppresses lipid accumulation and enhances energy expenditure. Moreover, anti‐CD146 antibodies inhibit obesity by disrupting the interactions between CD146 and its ligands. Together, these findings demonstrate that ANGPTL2 directly affects adipocytes via CD146 to promote obesity, suggesting that CD146 can be a potential target for treating obesity. The membrane receptor CD146 is a novel ANGPTL2 receptor that promotes obesity and insulin resistance. By interacting with ANGPTL2 and galectin‐1, CD146 enhances adipogenesis and lipogenesis while suppressing FAO and BAT thermogenesis. Furthermore, the disruption of the interaction between CD146 and its ligands by knocking out CD146 or using anti‐CD146 antibodies may prevent obesity and its related complications.
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影响因子：
4.2
作者：
Malyszko, J;Malyszko, JS;Mysliwiec, M
通讯作者：
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