Infant gut bacterial community composition and food-related manifestation of atopy in early childhood.
Infant gut bacterial community composition and food-related manifestation of atopy in early childhood.
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DOI：
10.1111/pai.13704
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发表时间：
2022-01
影响因子：
4.4
通讯作者：
Cole Johnson, Christine
中科院分区：
文献类型：
--
作者：
Joseph, Christine L. M.;Sitarik, Alexandra R.;Kim, Haejin;Huffnagle, Gary;Fujimura, Kei;Yong, Germaine Jia Min;Levin, Albert M.;Zoratti, Edward;Lynch, Susan;Ownby, Dennis R.;Lukacs, Nicholas W.;Davidson, Brent;Barone, Charles;Cole Johnson, Christine
免疫球蛋白e介导的食物过敏（IgE-FA）已成为全球关注的公共卫生问题。免疫失调是IgE-FA的潜在机制，由早期肠道微生物群的“生态失调”引起。我们调查了3-5岁婴儿肠道细菌组成与食物相关的特应性之间的关系，使用了一个特征良好的出生队列。鸡蛋，牛奶或花生中IgE-FA的研究定义是基于医师小组对从出生到3-5岁收集的临床和问卷数据的回顾性审查。使用16S rRNA测序，我们分析了1个月和6个月大的粪便标本中存在的细菌肠道微生物群。在447名有数据分析的婴儿中，44名（9.8%）符合医生小组对IgE-FA≥1的三种过敏原的审查标准。在3-5岁时被分类为IgE-FA的儿童中，与3-5岁时未被分类为IgE-FA的儿童相比，婴儿粪便样本的肠道微生物群多样性显着降低，特别是牛奶和花生（所有协变量调整的alpha指标p <.007）。单个操作分类单元（otu）检测显示，与不含IgE-FA的otu相比，有31个otu在6个月内缺乏IgE-FA，主要集中在乳酸杆菌目、拟杆菌目和梭菌目。婴儿粪便中肠道微生物组成的变化与3-5岁时IgE-FA的研究定义有关。这包括缺乏细菌多样性的证据，特定otu的缺陷，以及微生物成熟的延迟。结果支持IgE-FA发病机制中的生态失调。
Immunoglobulin E–mediated food allergy (IgE-FA) has emerged as a global public health concern. Immune dysregulation is an underlying mechanism for IgE-FA, caused by “dysbiosis” of the early intestinal microbiota. We investigated the association between infant gut bacterial composition and food-related atopy at age 3–5 years using a well-characterized birth cohort. The study definition of IgE-FA to egg, milk, or peanut was based on physician panel retrospective review of clinical and questionnaire data collected from birth through age 3–5 years. Using 16S rRNA sequencing, we profiled the bacterial gut microbiota present in stool specimens collected at 1 and 6 months of age. Of 447 infants with data for analysis, 44 (9.8%) met physician panel review criteria for IgE-FA to ≥1 of the three allergens. Among children classified as IgE-FA at 3–5 years, infant stool samples showed significantly less diversity of the gut microbiota compared with the samples of children classified as no IgE-FA at age 3–5 years, especially for milk and peanut (all covariate-adjusted p’s for alpha metrics <.007). Testing of individual operational taxonomic units (OTUs) revealed 6-month deficiencies in 31 OTUs for IgE-FA compared with no IgE-FA, mostly in the orders Lactobacillales, Bacteroidales, and Clostridiales. Variations in gut microbial composition in infant stool were associated with a study definition of IgE-FA at 3–5 years of age. This included evidence of a lack of bacterial diversity, deficiencies in specific OTUs, and delayed microbial maturation. Results support dysbiosis in IgE-FA pathogenesis.
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影响因子：
12.4
作者：
Savage JH;Lee-Sarwar KA;Sordillo J;Bunyavanich S;Zhou Y;O'Connor G;Sandel M;Bacharier LB;Zeiger R;Sodergren E;Weinstock GM;Gold DR;Weiss ST;Litonjua AA
通讯作者：
Litonjua AA
DOI：
10.1016/j.jaci.2010.10.007
发表时间：
2010-12
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
NIAID-Sponsored Expert Panel;Boyce JA;Assa'ad A;Burks AW;Jones SM;Sampson HA;Wood RA;Plaut M;Cooper SF;Fenton MJ;Arshad SH;Bahna SL;Beck LA;Byrd-Bredbenner C;Camargo CA Jr;Eichenfield L;Furuta GT;Hanifin JM;Jones C;Kraft M;Levy BD;Lieberman P;Luccioli S;McCall KM;Schneider LC;Simon RA;Simons FE;Teach SJ;Yawn BP;Schwaninger JM
通讯作者：
Schwaninger JM
影响因子：
64.8
作者：
Subramanian, Sathish;Huq, Sayeeda;Yatsunenko, Tanya;Haque, Rashidul;Mahfuz, Mustafa;Alam, Mohammed A.;Benezra, Amber;DeStefano, Joseph;Meier, Martin F.;Muegge, Brian D.;Barratt, Michael J.;VanArendonk, Laura G.;Zhang, Qunyuan;Province, Michael A.;Petri, William A., Jr.;Ahmed, Tahmeed;Gordon, Jeffrey I.
通讯作者：
Gordon, Jeffrey I.
影响因子：
12.3
作者：
Lloyd-Price J;Abu-Ali G;Huttenhower C
通讯作者：
Huttenhower C
影响因子：
5.6
作者：
Ezell, Jerel M.;Ownby, Dennis R.;Zoratti, Edward M.;Havstad, Suzanne;Nicholas, Charlotte;Nageotte, Christian;Misiak, Rana;Enberg, Robert;Johnson, Christine Cole;Joseph, Christine L. M.
通讯作者：
Joseph, Christine L. M.