Contribution of macrophages to fetomaternal immunological tolerance.
Contribution of macrophages to fetomaternal immunological tolerance.
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DOI：
10.1016/j.humimm.2021.02.013
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发表时间：
2021-05
期刊：
影响因子：
2.7
通讯作者：
Nayak NR
中科院分区：
文献类型：
--
作者：
Parasar P;Guru N;Nayak NR
半同种异体胎儿在子宫内独特的免疫耐受环境中发育。为了成功怀孕，先天性和适应性免疫系统都必须有利于接受胎儿同种异体移植物。巨噬细胞是蜕膜中仅次于自然杀伤（NK）细胞的第二大免疫细胞。巨噬细胞与蜕膜NK细胞和树突状细胞协同作用，有助于着床、血管重塑、胎盘发育、对胎盘细胞的免疫耐受以及维持母胎界面的组织稳态。蜕膜巨噬细胞在生长因子和细胞因子的局部环境的影响下表现出经典的活化（M1）和交替活化（M2）表型，并且适当的M1/M2开关的时间调节对于成功妊娠至关重要。在怀孕期间控制M1/M2平衡和相关功能的机制的紊乱可以触发一系列妊娠并发症，从先兆子痫和胎儿生长受限到早产。本文综述了耐受的各种机制，重点是巨噬细胞的基本生物学，其可塑性和极化，以及它们在免疫特权的母胎界面的保护作用，包括促进母胎免疫耐受的直接和间接作用。
The semi-allogeneic fetus develops in a uniquely immune tolerant environment within the uterus. For successful pregnancy, both the innate and adaptive immune systems must favor acceptance of the fetal allograft. Macrophages are the second most abundant immune cells after natural killer (NK) cells in the decidua. In coordination with decidual NK cells and dendritic cells, macrophages aid in implantation, vascular remodeling, placental development, immune tolerance to placental cells, and maintenance of tissue homeostasis at the maternal-fetal interface. Decidual macrophages show the classical activated (M1) and alternatively activated (M2) phenotypes under the influence of the local milieu of growth factors and cytokines, and appropriate temporal regulation of the M1/M2 switch is vital for successful pregnancy. Disturbances in the mechanisms that control the M1/M2 balance and associated functions during pregnancy can trigger a spectrum of pregnancy complications ranging from preeclampsia and fetal growth restriction to preterm delivery. This review addresses various mechanisms of tolerance, focusing on the basic biology of macrophages, their plasticity and polarization, and their protective roles at the immune-privileged maternal-fetal interface, including direct and indirect roles in promoting fetomaternal immune tolerance.
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DOI：
10.1111/j.1600-0897.2004.00156.x
发表时间：
2004-04-01
影响因子：
3.6
作者：
Abrahams, VM;Kim, YM;Mor, G
通讯作者：
Mor, G
影响因子：
--
作者：
Douglas NC;Zimmermann RC;Tan QK;Sullivan-Pyke CS;Sauer MV;Kitajewski JK;Shawber CJ
通讯作者：
Shawber CJ
影响因子：
7.3
作者：
Faas MM;Spaans F;De Vos P
通讯作者：
De Vos P
影响因子：
6
作者：
Harris, Lynda K.;Keogh, Rosemary J.;Whitley, Guy St J.
通讯作者：
Whitley, Guy St J.
影响因子：
4.6
作者：
Heikkinen, J;Möttönen, M;Lassila, O
通讯作者：
Lassila, O