Polybrominated diphenyl ethers (PBDEs) and bioaccumulative hydroxylated PBDE metabolites in young humans from Managua, Nicaragua.
Polybrominated diphenyl ethers (PBDEs) and bioaccumulative hydroxylated PBDE metabolites in young humans from Managua, Nicaragua.
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DOI：
10.1289/ehp.10713
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发表时间：
2008-03
影响因子：
10.4
通讯作者：
Jakobsson K
中科院分区：
文献类型：
--
作者：
Athanasiadou M;Cuadra SN;Marsh G;Bergman A;Jakobsson K
我们的目的是调查暴露于多溴联苯醚（PBDEs）在一个发展中国家的年轻城市人口，重点是潜在的高度暴露的儿童非正式工作，在一个大型城市垃圾处理场的废料清道夫。我们还着手研究是否可以检测到迄今为止尚未发现保留在人体中的羟基化代谢物。我们评估了2002年从马那瓜城市垃圾处理场工作（有时也生活）的11-15岁儿童和非工作城市儿童中采集的混合血清样本中的多溴二苯醚。在儿童和15-44岁年龄组的妇女中评估了鱼类消费的影响，这些妇女的鱼类消费量明显不同。羟基化多溴二苯醚作为其甲氧基化衍生物进行评估。使用真实参比物质通过气相色谱/质谱法进行化学分析。在废物处置场生活和工作的儿童体内的中溴化二苯醚含量非常高。在参照儿童中观察到的水平与美国当代的观察结果相当。暴露模式与灰尘是主要来源一致。多溴二苯醚含量最高的儿童体内羟基化代谢物含量也最高。出乎意料的是，在一个发展中国家的一个城市地区的儿童体内发现了非常高水平的多溴二苯醚。此外，还首次发现羟基化多溴二苯醚代谢物在人体血清中具有生物累积性。
Our aim was to investigate exposure to polybrominated diphenyl ethers (PBDEs) in a young urban population in a developing country, with focus on potentially highly exposed children working informally as scrap scavengers at a large municipal waste disposal site. We also set out to investigate whether hydroxylated metabolites, which not hitherto have been found retained in humans, could be detected. We assessed PBDEs in pooled serum samples obtained in 2002 from children 11–15 years of age, working and sometimes also living at the municipal waste disposal site in Managua, and in nonworking urban children. The influence of fish consumption was evaluated in the children and in groups of women 15–44 years of age who differed markedly in their fish consumption. Hydroxylated PBDEs were assessed as their methoxylated derivates. The chemical analyses were performed by gas chromatography/mass spectrometry, using authentic reference substances. The children living and working at the waste disposal site showed very high levels of medium brominated diphenyl ethers. The levels observed in the referent children were comparable to contemporary observations in the United States. The exposure pattern was consistent with dust being the dominating source. The children with the highest PBDE levels also had the highest levels of hydroxylated metabolites. Unexpectedly, very high levels of PBDEs were found in children from an urban area in a developing country. Also, for the first time, hydroxylated PBDE metabolites were found to bioaccumulate in human serum.
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影响因子：
11.4
作者：
Fängström, B;Hovander, L;Bergmant, Å
通讯作者：
Bergmant, Å
DOI：
10.1007/bf00325850
发表时间：
1993-06-01
期刊：
FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY
影响因子：
--
作者：
BALLSCHMITER, K;MENNEL, A;BUYTEN, J
通讯作者：
BUYTEN, J
影响因子：
8.8
作者：
Eslami, B;Koizumi, A;Ikeda, M
通讯作者：
Ikeda, M
DOI：
10.1016/j.jchromb.2005.09.020
发表时间：
2005-12-05
影响因子：
3
作者：
Covaci, A;Voorspoels, S
通讯作者：
Voorspoels, S
影响因子：
8.8
作者：
de Wit, Cynthia A.;Alaee, Mehran;Muir, Derek C. G.
通讯作者：
Muir, Derek C. G.