Changes in acid-base and ion balance during exercise in normoxia and normobaric hypoxia.
Changes in acid-base and ion balance during exercise in normoxia and normobaric hypoxia.
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DOI：
10.1007/s00421-017-3712-z
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发表时间：
2017-11
影响因子：
3
通讯作者：
Hochreiter M
中科院分区：
文献类型：
--
作者：
Lühker O;Berger MM;Pohlmann A;Hotz L;Gruhlke T;Hochreiter M
运动和缺氧都会引起酸碱平衡的复杂变化。本研究的目的是调查是否在激烈的体育锻炼在常氧和缺氧，修改后的物理化学方法提供了一个更好的了解酸碱平衡的变化比传统的Henderson-Hasselbalch方法。在这项前瞻性、随机、交叉试验中，19名健康男性在两个不同的研究日，一次在常氧期间，一次在常压缺氧期间（12%氧气，相当于海拔4500米），在自行车测力计上完成了运动试验，直到自愿疲劳。在运动试验期间和之后，分别根据改良的物理化学和Henderson-Hasselbalch方法对动脉血气进行采样和分析。峰值功率输出从常氧时的287 ± 9瓦下降到缺氧时的213 ± 6瓦（-26%，P < 0.001）。常氧和缺氧时，运动使动脉pH值分别降至7.21 ± 0.01和7.27 ± 0.02（P < 0.001），血浆乳酸分别升至16.8 ± 0.8和17.5 ± 0.9mmol/l（P < 0.001）。虽然Henderson-Hasselbalch方法将乳酸盐确定为非呼吸性酸中毒的主要因素，但改良的理化方法还将强离子（即血浆电解质、有机酸离子）和非挥发性弱酸（即白蛋白、磷酸根离子）确定为重要贡献者。Henderson-Hasselbalch方法可作为筛选酸碱失衡的基础，但改良的物理化学方法提供了更详细的了解运动过程中的酸碱状态在常氧和缺氧，分别复杂的变化。本文的在线版本（doi：10.1007/s 00421 -017-3712-z）包含补充材料，可供授权用户使用。
Both exercise and hypoxia cause complex changes in acid–base homeostasis. The aim of the present study was to investigate whether during intense physical exercise in normoxia and hypoxia, the modified physicochemical approach offers a better understanding of the changes in acid–base homeostasis than the traditional Henderson–Hasselbalch approach. In this prospective, randomized, crossover trial, 19 healthy males completed an exercise test until voluntary fatigue on a bicycle ergometer on two different study days, once during normoxia and once during normobaric hypoxia (12% oxygen, equivalent to an altitude of 4500 m). Arterial blood gases were sampled during and after the exercise test and analysed according to the modified physicochemical and Henderson–Hasselbalch approach, respectively. Peak power output decreased from 287 ± 9 Watts in normoxia to 213 ± 6 Watts in hypoxia (−26%, P < 0.001). Exercise decreased arterial pH to 7.21 ± 0.01 and 7.27 ± 0.02 (P < 0.001) during normoxia and hypoxia, respectively, and increased plasma lactate to 16.8 ± 0.8 and 17.5 ± 0.9 mmol/l (P < 0.001). While the Henderson–Hasselbalch approach identified lactate as main factor responsible for the non-respiratory acidosis, the modified physicochemical approach additionally identified strong ions (i.e. plasma electrolytes, organic acid ions) and non-volatile weak acids (i.e. albumin, phosphate ion species) as important contributors. The Henderson–Hasselbalch approach might serve as basis for screening acid–base disturbances, but the modified physicochemical approach offers more detailed insights into the complex changes in acid–base status during exercise in normoxia and hypoxia, respectively. The online version of this article (doi:10.1007/s00421-017-3712-z) contains supplementary material, which is available to authorized users.
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