Differences in neural activation as a function of risk-taking task parameters.
Differences in neural activation as a function of risk-taking task parameters.
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DOI：
10.3389/fnins.2013.00173
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发表时间：
2013
影响因子：
4.3
通讯作者：
Poldrack RA
中科院分区：
文献类型：
--
作者：
Congdon E;Bato AA;Schonberg T;Mumford JA;Karlsgodt KH;Sabb FW;London ED;Cannon TD;Bilder RM;Poldrack RA
尽管有证据支持冲动和自然冒险之间的关系，冲动与基于实验室的风险决策措施之间的关系仍然不清楚。造成这种理解上的差距的一个因素是，不同的风险决策任务在细节上的差异程度。我们对钓鱼风险任务（ART）进行了fMRI调查，这是一种改进的风险决策行为测量方法。为了检查所观察到的神经激活模式是特定于ART还是可推广的，我们还检查了23名健康成年人的同一样本中的气球模拟冒险（BART）任务的相关性。进行了探索性分析，以检查神经激活，性能，冲动和自我报告的冒险之间的关系。虽然估值网络中的激活与ART期间的奖励跟踪相关，但与BART无关，但与ART相比，BART中的风险选择试验期间可以看到额扣带回激活增加。因此，风险决策试验期间的神经激活在两项任务之间存在差异，这一观察结果可能是由任务参数的差异驱动的，即，分别是ART和BART上不存在与存在模糊和/或固定与增加的丢失概率。探索性关联分析表明，在ART过程中，神经反应对潜在奖励大小的敏感性与次优的表现策略、功能障碍性冲动（DI）量表上的较高得分以及从事危险行为的可能性较大相关，而在BART中没有看到这种模式。我们的研究结果表明，ART是可分解的，与不同的神经激活模式相关;这代表了表征风险决策的行为测量的初步步骤，其可以支持对自然主义冒险的更好理解。
Despite evidence supporting a relationship between impulsivity and naturalistic risk-taking, the relationship of impulsivity with laboratory-based measures of risky decision-making remains unclear. One factor contributing to this gap in our understanding is the degree to which different risky decision-making tasks vary in their details. We conducted an fMRI investigation of the Angling Risk Task (ART), which is an improved behavioral measure of risky decision-making. In order to examine whether the observed pattern of neural activation was specific to the ART or generalizable, we also examined correlates of the Balloon Analog Risk Taking (BART) task in the same sample of 23 healthy adults. Exploratory analyses were conducted to examine the relationship between neural activation, performance, impulsivity and self-reported risk-taking. While activation in a valuation network was associated with reward tracking during the ART but not the BART, increased fronto-cingulate activation was seen during risky choice trials in the BART as compared to the ART. Thus, neural activation during risky decision-making trials differed between the two tasks, and this observation was likely driven by differences in task parameters, namely the absence vs. presence of ambiguity and/or stationary vs. increasing probability of loss on the ART and BART, respectively. Exploratory association analyses suggest that sensitivity of neural response to the magnitude of potential reward during the ART was associated with a suboptimal performance strategy, higher scores on a scale of dysfunctional impulsivity (DI) and a greater likelihood of engaging in risky behaviors, while this pattern was not seen for the BART. Our results suggest that the ART is decomposable and associated with distinct patterns of neural activation; this represents a preliminary step toward characterizing a behavioral measure of risky decision-making that may support a better understanding of naturalistic risk-taking.
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DOI：
10.1523/jneurosci.0919-12.2013
发表时间：
2013-01-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Jimura K;Chushak MS;Braver TS
通讯作者：
Braver TS
影响因子：
4.7
作者：
Bjork, James M.;Smith, Ashley R.;Chen, Gang;Hommer, Daniel W.
通讯作者：
Hommer, Daniel W.
影响因子：
25
作者：
Buckholtz, Joshua W.;Treadway, Michael T.;Cowan, Ronald L.;Woodward, Neil D.;Benning, Stephen D.;Li, Rui;Ansari, M. Sib;Baldwin, Ronald M.;Schwartzman, Ashley N.;Shelby, Evan S.;Smith, Clarence E.;Cole, David;Kessler, Robert M.;Zald, David H.
通讯作者：
Zald, David H.
影响因子：
4.2
作者：
Fernie, Gordon;Cole, Jon C.;Field, Matt
通讯作者：
Field, Matt
影响因子：
3.4
作者：
Galvan, Adriana;Schonberg, Tom;Mumford, Jeanette;Kohno, Milky;Poldrack, Russell A.;London, Edythe D.
通讯作者：
London, Edythe D.