Abnormal patterns of regional homogeneity and functional connectivity across the adolescent first-episode, adult first-episode and adult chronic schizophrenia.
Abnormal patterns of regional homogeneity and functional connectivity across the adolescent first-episode, adult first-episode and adult chronic schizophrenia.
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青少年第一集，成人第一集和成人慢性精神分裂症的区域同质性和功能连通性的异常模式。
DOI：
10.1016/j.nicl.2022.103198
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发表时间：
2022
影响因子：
4.2
通讯作者：
Lv, Luxian
中科院分区：
文献类型：
--
作者：
Yang, Yongfeng;Sun, Yuqing;Zhang, Yuliang;Jin, Xueyan;Li, Zheng;Ding, Minli;Shi, Han;Liu, Qing;Zhang, Luwen;Su, Xi;Shao, Minglong;Song, Meng;Zhang, Yan;Li, Wenqiang;Yue, Weihua;Liu, Bing;Lv, Luxian
关键词：
本研究纳入不同分期的SZ患者，进一步丰富了神经发育异常的理论基础。MFG和壳核的REHO异常可能是SZ三个不同阶段常见的异常模式。VmPFC-dlPFC和DMN网络异常多见于青春期和成年期。精神分裂症(SZ)的功能缺陷是在精神病发作之前观察到的，并在SZ的不同阶段有所不同。然而，针对青少年首发SZ(AOS)、成人首发SZ(AFES)和成人慢性SZ(CHSZ)的研究较少。在这项研究中，我们调查了区域活动和相应的功能连通性变化，目的是同时比较这三个疾病阶段。受试者包括49名AOS患者、57名AFES患者、51名CHSZ患者、41名青少年健康对照和138名成人健康对照。我们比较了每个疾病阶段的患者与匹配的健康对照组之间的区域同质性(REHO)。我们重点研究了SZ患者在三个不同疾病阶段与健康对照组之间显示出显著差异的共同大脑区域。进一步的分析是为了探索整个大脑功能连通性变化的模式是否相似。在AOS、AFES和CHSZ中，壳核和内侧额回(MFG)表现出一致的异常模式。在AOS、AFES和CHSZ中，MFG的ReHO值普遍降低，而双侧壳核的ReHO值增加。在不同的SZ分期中，MFG的功能连接性仍然是常见的异常。综上所述，MFG和壳核的ReHO异常可能是SZ三个不同阶段常见的脑功能异常模式。VmPFC-dlPFC异常多见于青春期和成年期。这项研究可能对AOS、AFES和CHSZ的神经发育异常有更全面的了解。
This study included different stage of SZ patients further enrich the theoretical basis for neurodevelopmental abnormalities. ReHo abnormalities in the MFG and putamen may be common abnormal patterns in the three different stages of SZ. The vmPFC-dlPFC FC and DMN network abnormality common occur in adolescence and adulthood. Functional deficits in schizophrenia (SZ) are observed prior to the onset of psychosis and differ at different stages of SZ. However, there is a paucity of studies focused on adolescent first-episode SZ (AOS), adult first-episode SZ (AFES), and adult chronic SZ (CHSZ). In this study, we investigated regional activity and corresponding functional connectivity alterations that have aimed to compare the three disease stages simultaneously. The subjects comprised 49 patients with AOS, 57 patients with AFES, 51 patients with CHSZ, 41 adolescent healthy controls, and 138 adult healthy controls. We compared regional homogeneity (ReHo) between patients at each disease stage with matched healthy controls. We focused on the shared brain regions that showed significant differences between SZ patients at the three different disease stages and healthy controls. Further analysis was conducted to explore whether the patterns of the whole brain functional connectivity alterations were similar. The putamen and medial frontal gyrus (MFG) showed consistently abnormal patterns in AOS, AFES, and CHSZ. Commonly decreased ReHo values in the MFG and increased ReHo values in the bilateral putamen were found in AOS, AFES, and CHSZ. Functional connectivity of MFG remained common abnormality in different SZ stage. In conclusion, ReHo abnormalities in the MFG and the putamen may be common abnormal patterns of brain function in the three different stages of SZ. The vmPFC-dlPFC FC abnormality common occurs in adolescence and adulthood.. This study may provide a more comprehensive understanding of the neurodevelopmental abnormality across the AOS, AFES, and CHSZ.
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影响因子：
3.2
作者：
Talati, A;Hirsch, J
通讯作者：
Hirsch, J
影响因子：
4.5
作者：
Watsky RE;Gotts SJ;Berman RA;McAdams HM;Zhou X;Greenstein D;Lalonde FM;Gochman P;Clasen LS;Shora L;Ordóñez AE;Gogtay N;Martin A;Barch DM;Rapoport JL;Liu S
通讯作者：
Liu S
影响因子：
2.3
作者：
Frascarelli, Marianna;Tognin, Stefania;Fusar-Poli, Paolo
通讯作者：
Fusar-Poli, Paolo
影响因子：
4.5
作者：
Fraguas, David;Diaz-Caneja, Covadonga M.;Arango, Celso
通讯作者：
Arango, Celso
精神分裂症患者及其未受影响的兄弟姐妹之间都存在异常增加且不连贯的静息状态活动
影响因子：
4.5
作者：
Liu, Chang;Xue, Zhimin;Pu, Weidan
通讯作者：
Pu, Weidan