Airway microbiome-immune crosstalk in chronic obstructive pulmonary disease.
Airway microbiome-immune crosstalk in chronic obstructive pulmonary disease.
复制标题
慢性阻塞性肺疾病中气道微生物组与免疫系统的相互作用
DOI：
10.3389/fimmu.2022.1085551
复制
发表时间：
2022
影响因子：
7.3
通讯作者：
Forslund, Sofia K.
中科院分区：
文献类型：
--
作者：
Kayongo, Alex;Robertson, Nicole M.;Siddharthan, Trishul;Ntayi, Moses Levi;Ndawula, Josephine Caren;Sande, Obondo J.;Bagaya, Bernard S.;Kirenga, Bruce;Mayanja-Kizza, Harriet;Joloba, Moses L.;Forslund, Sofia K.
慢性阻塞性肺疾病（COPD）是全球死亡率的主要原因，每年报告的死亡人数为300万。这种影响预计将在未来40年内增加，预计每年约有500万人死于COPD相关死亡。驱动疾病进展的免疫机制尚未完全阐明。呼吸道微生物群也有牵连。然而，目前尚不清楚气道微生物组的变化如何驱动持续的免疫激活和随之而来的肺损伤。介导气道中微生物组免疫串扰的机制仍不清楚。在这篇综述中，我们研究了生态失调如何介导COPD气道炎症。我们给出了一个详细的说明如何气道细菌相互作用的粘膜先天性和适应性免疫系统，以调节免疫反应，在健康或患病的气道。免疫表型气道微生物群可以促进COPD免疫治疗，并确定未来研究必须解决的关键开放问题，以进一步进行此类转化。
Chronic Obstructive Pulmonary Disease (COPD) has significantly contributed to global mortality, with three million deaths reported annually. This impact is expected to increase over the next 40 years, with approximately 5 million people predicted to succumb to COPD-related deaths annually. Immune mechanisms driving disease progression have not been fully elucidated. Airway microbiota have been implicated. However, it is still unclear how changes in the airway microbiome drive persistent immune activation and consequent lung damage. Mechanisms mediating microbiome-immune crosstalk in the airways remain unclear. In this review, we examine how dysbiosis mediates airway inflammation in COPD. We give a detailed account of how airway commensal bacteria interact with the mucosal innate and adaptive immune system to regulate immune responses in healthy or diseased airways. Immune-phenotyping airway microbiota could advance COPD immunotherapeutics and identify key open questions that future research must address to further such translation.
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影响因子：
5.6
作者：
通讯作者：
--
影响因子：
5.8
作者：
Agusti A;Calverley PM;Celli B;Coxson HO;Edwards LD;Lomas DA;MacNee W;Miller BE;Rennard S;Silverman EK;Tal-Singer R;Wouters E;Yates JC;Vestbo J;Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators
通讯作者：
Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators
影响因子：
64.8
作者：
Alenghat, Theresa;Osborne, Lisa C.;Saenz, Steven A.;Kobuley, Dmytro;Ziegler, Carly G. K.;Mullican, Shannon E.;Choi, Inchan;Grunberg, Stephanie;Sinha, Rohini;Wynosky-Dolfi, Meghan;Snyder, Annelise;Giacomin, Paul R.;Joyce, Karen L.;Hoang, Tram B.;Bewtra, Meenakshi;Brodsky, Igor E.;Sonnenberg, Gregory F.;Bushman, Frederic D.;Won, Kyoung-Jae;Lazar, Mitchell A.;Artis, David
通讯作者：
Artis, David
DOI：
10.1152/ajplung.00061.2019
发表时间：
2019-11-01
影响因子：
4.9
作者：
Andrault, Pierre-Marie;Schamberger, Andrea C.;Lecaille, Fabien
通讯作者：
Lecaille, Fabien
特发性肺纤维化中的下呼吸道微生物组和抗菌肽与慢性阻塞性肺疾病不同。
影响因子：
3.7
作者：
Knudsen KS;Lehmann S;Nielsen R;Tangedal S;Haaland I;Hiemstra PS;Eagan TM
通讯作者：
Eagan TM