dbGSRV: A manually curated database of genetic susceptibility to respiratory virus.

dbGSRV: A manually curated database of genetic susceptibility to respiratory virus.
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DOI:
10.1371/journal.pone.0262373
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发表时间:
2022
期刊:
影响因子:
3.7
通讯作者:
Zhao Z
Zhao Z
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Li P;Zhang Y;Shen W;Shi S;Zhao Z

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人类遗传学已被认为在呼吸道病毒感染发生和结果的个体间差异中发挥重要作用。为了系统地了解人类遗传对呼吸道病毒感染的贡献,我们开发了数据库dbGSRV,这是一个手动管理的数据库,整合了分散在PubMed文献中的呼吸道病毒的宿主遗传易感性和严重性研究。目前,dbGSRV包含1932条遗传关联研究记录,涉及1010种独特变异和7种呼吸道病毒,这些记录是从168篇已发表的文章中手动整理的。用户可以通过快速查询、批量查询、高级查询和浏览等方式访问记录。每个记录都提供了参考信息、感染状况、人口信息、突变信息和疾病关系,并提供了公共数据库的超链接,以方便用户访问更多信息。此外,提供了呼吸道病毒和相关基因之间的拓扑网络关系的可视化概述。因此,dbGSRV为研究人员浏览和检索与呼吸道病毒的遗传关联提供了方便的资源,这可能会激发未来的研究,并为我们理解和治疗呼吸道病毒感染提供新的见解。数据库URL:http://www.ehbio.com/dbGSRV/front/
Human genetics has been proposed to play an essential role in inter-individual differences in respiratory virus infection occurrence and outcomes. To systematically understand human genetic contributions to respiratory virus infection, we developed the database dbGSRV, a manually curated database that integrated the host genetic susceptibility and severity studies of respiratory viruses scattered over literatures in PubMed. At present, dbGSRV contains 1932 records of genetic association studies relating 1010 unique variants and seven respiratory viruses, manually curated from 168 published articles. Users can access the records by quick searching, batch searching, advanced searching and browsing. Reference information, infection status, population information, mutation information and disease relationship are provided for each record, as well as hyperlinks to public databases in convenient of users accessing more information. In addition, a visual overview of the topological network relationship between respiratory viruses and associated genes is provided. Therefore, dbGSRV offers a convenient resource for researchers to browse and retrieve genetic associations with respiratory viruses, which may inspire future studies and provide new insights in our understanding and treatment of respiratory virus infection. Database URL: http://www.ehbio.com/dbGSRV/front/
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