Interaction between β-hexachlorocyclohexane and ADIPOQ genotypes contributes to the risk of type 2 diabetes mellitus in East Chinese adults.
Interaction between β-hexachlorocyclohexane and ADIPOQ genotypes contributes to the risk of type 2 diabetes mellitus in East Chinese adults.
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β-六氯环己烷和 ADIPOQ 基因型之间的相互作用增加了华东成年人患 2 型糖尿病的风险。
DOI：
10.1038/srep37769
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发表时间：
2016-11-24
影响因子：
4.6
通讯作者：
Wang SL
中科院分区：
文献类型：
--
作者：
Li S;Wang X;Yang L;Yao S;Zhang R;Xiao X;Zhang Z;Wang L;Xu Q;Wang SL
越来越多的证据表明环境中暴露于六氯环己烷（HCHs）与2型糖尿病（T2 DM）的风险有关，而编码脂联素的ADIPOQ被认为是T2 DM的重要基因。然而，ADIPOQ-HCH相互作用对2型糖尿病风险的作用仍不清楚。因此，在华东社区进行了配对病例对照研究。共纳入1446名受试者，包括723名病例和723名年龄、性别和居住地相匹配的对照，并使用GC-MS/MS检测血清样品中的4种HCH异构体。（rs 182052、rs 266729、rs6810075和rs 16861194）通过TaqMan测定进行基因分型，并且使用ELISA测量血浆脂联素。4个SNPs位点与T2 DM风险无相关性，但与β-HCH水平相关（P < 0.001）。此外，β-HCH和rs 182052之间的协同交互作用显著增加了2型糖尿病的风险（OR I-相加模型= 2.20，OR I-隐性模型= 2.13）。此外，仅携带rs 182052（A等位基因）且β-HCH水平高的个体脂联素水平显著降低（P = 0.016）。这些结果表明，rs 182052和β-HCH之间的相互作用可能会通过共同降低脂联素水平来增加2型糖尿病的风险，并可能引发2型糖尿病的发生。
Growing evidence links environmental exposure to hexachlorocyclohexanes (HCHs) to the risk of type 2 diabetes mellitus (T2DM), and ADIPOQ that encodes adiponectin is considered as an important gene for T2DM. However, the role of ADIPOQ-HCH interaction on T2DM risk remains unclear. Thus, a paired case-control study was conducted in an East Chinese community. A total of 1446 subjects, including 723 cases and 723 controls matched on age, gender and residence, were enrolled, and 4 types of HCH isomers were measured in serum samples using GC-MS/MS. Additionally, 4 candidate ADIPOQ SNPs (rs182052, rs266729, rs6810075, and rs16861194) were genotyped by TaqMan assay, and plasma adiponectin was measured using ELISA. No associations between 4 SNPs and T2DM risk were found, but T2DM risk significantly increased with serum levels of β-HCH (P < 0.001). Furthermore, the synergistic interaction between β-HCH and rs182052 significantly increased T2DM risk (OR I-additive model = 2.20, OR I-recessive model = 2.13). Additionally, individuals carrying only rs182052 (A allele) with high levels of β-HCH had significant reduction in adiponectin levels (P = 0.016). These results indicate that the interaction between rs182052 and β-HCH might increase the risk of T2DM by jointly decreasing the adiponectin level and potentially trigger T2DM development.
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