Association between 3801T>C polymorphism of CYP1A1 and idiopathic male infertility risk: a systematic review and meta-analysis.
Association between 3801T>C polymorphism of CYP1A1 and idiopathic male infertility risk: a systematic review and meta-analysis.
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DOI：
10.1371/journal.pone.0086649
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
He T
中科院分区：
文献类型：
--
作者：
Luo H;Li H;Yao N;Hu L;He T
已有流行病学研究评价了CYP 1A 1基因3801 T>C多态性与特发性男性不育风险的关系，但结果不确定。我们的目的是通过对病例对照研究进行荟萃分析来得出更精确的关系估计。本研究符合系统性综述和荟萃分析指南的首选报告项目。检索了截至2013年11月的PubMed、Embase和CNKI数据库，以识别相关研究。合并比值比和95%置信区间用于评估CYP 1A 1 3801 T>C多态性与特发性男性不育风险之间的关联强度。采用Q检验评价研究间异质性，采用漏斗图评价发表偏倚。进行敏感性分析，以评价荟萃分析结果的稳健性。本荟萃分析纳入了6项研究，涉及1，060例病例和1，225例对照。总的来说，在等位基因比较（OR = 1.36，95%CI：1.01-1.83）、纯合子模型（OR = 2.18，95%CI：1.15-4.12）和隐性模型（OR = 1.86，95%CI：1.09-3.20）中观察到3801 T>C多态性与特发性男性不育风险之间的显著关联，根据敏感性分析，结果是可靠的。 然而，在所有比较中，亚组分析并未进一步确定特发性男性不育的易感性。漏斗图检查未发现发表偏倚的证据。目前的荟萃分析提供了CYP 1A 1 3801 T>C多态性与特发性男性不育风险之间显著相关的证据。考虑到从合格研究继承的局限性，需要在大规模和设计良好的研究中进一步证实。
Epidemiological studies have evaluated the association between 3801T>C polymorphism of CYP1A1 gene and the risk for idiopathic male infertility, but the results are inconclusive. We aimed to derive a more precise estimation of the relationship by conducting a meta-analysis of case-control studies. This study conformed to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Embase and CNKI databases were searched through November 2013 to identify relevant studies. Pooled odds ratios with 95% confidence intervals were used to assess the strength of the association between CYP1A1 3801T>C polymorphism and idiopathic male infertility risk. Q-test was performed to evaluate between-study heterogeneity and publication bias was appraised using funnel plots. Sensitivity analyses were conducted to evaluate the robustness of meta-analysis findings. Six studies involving 1,060 cases and 1,225 controls were included in this meta-analysis. Overall, significant associations between 3801T>C polymorphism and idiopathic male infertility risk were observed in allelic comparison (OR = 1.36, 95% CI: 1.01–1.83), homozygous model (OR = 2.18, 95% CI: 1.15–4.12), and recessive model (OR = 1.86, 95% CI: 1.09–3.20), with robust findings according to sensitivity analyses. However, subgroup analyses did not further identify the susceptibility to idiopathic male infertility in all comparisons. Funnel plot inspections did not reveal evidence of publication bias. The current meta-analysis provides evidence of a significant association between CYP1A1 3801T>C polymorphism and idiopathic male infertility risk. Considering the limitation inherited from the eligible studies, further confirmation in large-scale and well-designed studies is needed.
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DOI：
10.1016/s1521-6934(02)00147-5
发表时间：
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影响因子：
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