Gestational exposure to low dose bisphenol A alters social behavior in juvenile mice.
Gestational exposure to low dose bisphenol A alters social behavior in juvenile mice.
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DOI：
10.1371/journal.pone.0025448
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Rissman EF
中科院分区：
文献类型：
--
作者：
Wolstenholme JT;Taylor JA;Shetty SR;Edwards M;Connelly JJ;Rissman EF
双酚A（BPA）是一种人造化合物，用于制造聚碳酸酯塑料和环氧树脂; BPA暴露可以减少大脑和某些行为的性别差异，这一发现引发了公众健康问题。我们询问在人类测量范围内，在怀孕期间摄入的低BPA剂量是否会影响青春期前小鼠的社会行为。我们注意到社会交往中的性别差异，女性花更多的时间并排坐着，而男性则更多地探索和独自坐着。此外，双酚A增加了显示鼻子到鼻子的接触，发挥招标和方法在两种性别。性别和饮食之间的相互作用被发现为自我梳理，社会交往，而并排坐在后面的其他鼠标。在所有这些情况下，控制和BPA女性之间的差异产生的相互作用。我们检查了妊娠晚期胚胎的大脑，以确定基因表达差异是否与我们观察到的一些性二态性或BPA影响的行为相关。由于BPA治疗在出生时就结束了，我们在胚胎发育期间取出大脑，以增加发现BPA介导效应的可能性。我们也选择这个胚胎年龄（E18.5），因为它与大脑性别分化的开始相吻合。有趣的是，谷氨酸转运体Slc1a1的mRNA在雌性大脑中暴露于BPA时增强。我们还注意到BPA改变了三种DNA甲基转移酶基因中的两种基因Dnmt1和Dnmt3a的表达。我们建议BPA影响神经发育过程中Sc1a1的DNA甲基化。青少年社会互动中的性别差异受到BPA的影响，特别是这种化合物会改变女性的行为。
Bisphenol A (BPA) is a man-made compound used to make polycarbonate plastics and epoxy resins; public health concerns have been fueled by findings that BPA exposure can reduce sex differences in brain and some behaviors. We asked if a low BPA dose, within the range measured in humans, ingested during pregnancy, would affect social behaviors in prepubertal mice. We noted sex differences in social interactions whereby females spent more time sitting side-by-side, while males engaged in more exploring and sitting alone. In addition BPA increased display of nose-to-nose contacts, play solicitations and approaches in both sexes. Interactions between sex and diet were found for self grooming, social interactions while sitting side-by-side and following the other mouse. In all these cases interactions were produced by differences between control and BPA females. We examined brains from embryos during late gestation to determine if gene expression differences might be correlated with some of the sexually dimorphic or BPA affected behaviors we observed. Because BPA treatments ended at birth we took the brains during embryogenesis to increase the probability of discovering BPA mediated effects. We also selected this embryonic age (E18.5) because it coincides with the onset of sexual differentiation of the brain. Interestingly, mRNA for the glutamate transporter, Slc1a1, was enhanced by exposure to BPA in female brains. Also we noted that BPA changed the expression of two of the three DNA methyltransferase genes, Dnmt1 and Dnmt3a. We propose that BPA affects DNA methylation of Sc1a1 during neural development. Sex differences in juvenile social interactions are affected by BPA and in particular this compound modifies behavior in females.
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影响因子：
10.4
作者：
Braun JM;Yolton K;Dietrich KN;Hornung R;Ye X;Calafat AM;Lanphear BP
通讯作者：
Lanphear BP
影响因子：
16.2
作者：
Insel, Thomas R.
通讯作者：
Insel, Thomas R.
影响因子：
7.4
作者：
Hajszan, Tibor;Leranth, Csaba
通讯作者：
Leranth, Csaba
影响因子：
7.4
作者：
Arnold, Arthur P.;Chen, Xuqi
通讯作者：
Chen, Xuqi
影响因子：
25
作者：
Aoyama, K;Suh, SW;Swanson, RA
通讯作者：
Swanson, RA